Technology Process of (2S,3S,6S)-3-Benzyloxy-6-(1-ethoxy-ethoxymethyl)-2-methoxy-3-methyl-tetrahydro-pyran
There total 8 articles about (2S,3S,6S)-3-Benzyloxy-6-(1-ethoxy-ethoxymethyl)-2-methoxy-3-methyl-tetrahydro-pyran which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 16 h
2: 98 percent / H2 / 5percent Pd/C / ethyl acetate / 0.25 h / 2585.7 Torr
3: 70 percent / benzene / 2 h / Ambient temperature
4: 1.) mercuric acetate, 2.) 3 M NaOH, NaBH4 / 1.) THF, H2O, 1.5 h, 2.) 15 min
5: 1.) NaH, 2.) Bu4NI / 1.) THF, 15 min, 2.) 12 h
With
sodium hydroxide; sodium tetrahydroborate; mercury(II) diacetate; hydrogen; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate; benzene;
DOI:10.1021/jo00345a007
- Guidance literature:
-
Multi-step reaction with 7 steps
1: K2CO3 / methanol / Ambient temperature; overnight
2: 9.7 g / pyridinium dichromate, Celite / CH2Cl2 / 12 h
3: 95 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 16 h
4: 98 percent / H2 / 5percent Pd/C / ethyl acetate / 0.25 h / 2585.7 Torr
5: 70 percent / benzene / 2 h / Ambient temperature
6: 1.) mercuric acetate, 2.) 3 M NaOH, NaBH4 / 1.) THF, H2O, 1.5 h, 2.) 15 min
7: 1.) NaH, 2.) Bu4NI / 1.) THF, 15 min, 2.) 12 h
With
sodium hydroxide; sodium tetrahydroborate; dipyridinium dichromate; Celite; mercury(II) diacetate; hydrogen; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate; benzene;
DOI:10.1021/jo00345a007
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 9.7 g / pyridinium dichromate, Celite / CH2Cl2 / 12 h
2: 95 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 16 h
3: 98 percent / H2 / 5percent Pd/C / ethyl acetate / 0.25 h / 2585.7 Torr
4: 70 percent / benzene / 2 h / Ambient temperature
5: 1.) mercuric acetate, 2.) 3 M NaOH, NaBH4 / 1.) THF, H2O, 1.5 h, 2.) 15 min
6: 1.) NaH, 2.) Bu4NI / 1.) THF, 15 min, 2.) 12 h
With
sodium hydroxide; sodium tetrahydroborate; dipyridinium dichromate; Celite; mercury(II) diacetate; hydrogen; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate; benzene;
DOI:10.1021/jo00345a007
