N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]benzamide

Base Information

Chemical Name:N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]benzamide
CAS No.:747411-49-0
Molecular Formula:C₁₇H₁₈N₂O₂
Molecular Weight:282.342
Hs Code.:
DSSTox Substance ID:DTXSID201214216
ChEMBL ID:CHEMBL1581191

Synonyms:MLS001173867;CHEMBL1581191;DTXSID201214216;HMS2905I07;AKOS001444566;SMR000595805;Z27512514;N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]benzamide;747411-49-0

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]benzamide

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:282.136827821
Heavy Atom Count:21
Complexity:354

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)C)NC(=O)CNC(=O)C2=CC=CC=C2

Technology Process of N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]benzamide

There total 4 articles about N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18865-38-8
Glycine xylidide

: 98-88-4
benzoyl chloride

: 747411-49-0
N-(2-(2,6-dimethylphenylamino)-2-oxoethyl)benzamide

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 2.5h;
DOI:10.1007/s00044-013-0474-y

Reference yield:

: 87-62-7
2,6-dimethylaniline

: 747411-49-0
N-(2-(2,6-dimethylphenylamino)-2-oxoethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide / 0.17 h / -20 °C

1.2: 4 h / 20 °C

2.1: trifluoroacetic acid / 0.5 h / 20 °C

3.1: dichloromethane / 2.5 h / 0 - 20 °C

With 4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-013-0474-y

Reference yield:

: 65-85-0,8013-63-6
benzoic acid

: 747411-49-0
N-(2-(2,6-dimethylphenylamino)-2-oxoethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / Reflux

2: dichloromethane / 2.5 h / 0 - 20 °C

With thionyl chloride; In dichloromethane;
DOI:10.1007/s00044-013-0474-y