4-(diethoxyMethyl)pyriMidin-2-aMine

Base Information

• Chemical Name: 4-(diethoxyMethyl)pyriMidin-2-aMine
• CAS No.: 1014-03-5
• Molecular Formula: C₉H₁₅N₃O₂
• Molecular Weight: 197.237
• Mol file: 1014-03-5.mol

Synonyms:

Chemical Property of 4-(diethoxyMethyl)pyriMidin-2-aMine

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(diethoxyMethyl)pyriMidin-2-aMine

There total 5 articles about 4-(diethoxyMethyl)pyriMidin-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,1-diethoxybut-3-yn-2-one (25234-85-9) + guanidine hydrochloride (50-01-1) → 2-Amino-pyrimidin-aldehyd-(4)-diaethylacetal (1014-03-5)

Guidance literature:

guanidine hydrochloride; With sodium hydride; In ethanol; at 20 ℃; for 0.25h; Inert atmosphere;

1,1-diethoxybut-3-yn-2-one; In ethanol; at 20 ℃; for 0.75h; Inert atmosphere;

DOI:10.1055/s-0031-1289294

Reference yield:

→ 2-Amino-pyrimidin-aldehyd-(4)-diaethylacetal (1014-03-5)

Guidance literature:

With palladium on activated charcoal; ammonia; Hydrogenation;

DOI:10.1021/ja01204a044

Reference yield:

3,3,4,4-tetraethoxybut-1-yne (851900-14-6) → 2-Amino-pyrimidin-aldehyd-(4)-diaethylacetal (1014-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / tetrahydrofuran; water / 4 h / Reflux

2.1: sodium hydride / ethanol / 0.25 h / 20 °C / Inert atmosphere

2.2: 0.75 h / 20 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; water;

DOI:10.1055/s-0031-1289294

upstream raw materials:

3,3,4,4-tetraethoxybut-1-yne

1,1-diethoxybut-3-yn-2-one

guanidine hydrochloride