EMpagliflozin iMpurity 10

Base Information

Chemical Name:EMpagliflozin iMpurity 10
CAS No.:2069942-68-1
Molecular Formula:C₃₂H₃₇ClO₁₂
Molecular Weight:649.092
Hs Code.:

Synonyms:

Suppliers and Price of EMpagliflozin iMpurity 10

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of EMpagliflozin iMpurity 10

Chemical Property:

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of EMpagliflozin iMpurity 10

There total 11 articles about EMpagliflozin iMpurity 10 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1279691-36-9
(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

: 108-24-7
acetic anhydride

: 2069942-68-1
(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran;
DOI:10.1021/ol501755h

Reference yield:

: 915095-96-4
methyl-1-C-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucopyranoside

: 108-24-7
acetic anhydride

: 2069942-68-1
methyl-2,4,6-tetra-O-acetyl-1-C-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucopyranoside

Guidance literature:: With dmap; In pyridine; dichloromethane; at -5 - 30 ℃; Large scale;

Reference yield:

: 915095-87-3
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone

: 2069942-68-1
(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 °C

2: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.5 h / -20 - 10 °C

3: hydrogenchloride / isopropyl alcohol / 5 h / 38 - 42 °C / pH 2

4: hydrogenchloride / isopropyl alcohol; methanol

5: triethylamine; dmap / tetrahydrofuran

With hydrogenchloride; dmap; aluminum (III) chloride; 1,1,3,3-Tetramethyldisiloxane; isopropylmagnesium chloride; triethylamine; lithium chloride; In tetrahydrofuran; methanol; isopropyl alcohol; toluene;
DOI:10.1021/ol501755h