915095-96-4

Upstream product

• 915095-94-2 (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran 
• 32469-28-6 (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one 
• 90-80-2 D-Glucono-1,5-lactone 
• 67-56-1 methanol 
• 915095-89-5 (S)-4-bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)benzene 

Downstream Products

• 864070-44-0 empagliflozin 
• 1417573-74-0 1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucopyranoside 
• 2069942-68-1 methyl-2,4,6-tetra-O-acetyl-1-C-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucopyranoside 
• 915095-99-7 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate 

Relevant academic research and scientific papers

A SYNTHESIS METHOD OF GLIFLOZIN USING CONTINUOUS PROCESS

The present invention relates to a method for gliflozin synthesis, comprising the steps of: (a) preparing a first product by making a stream comprising an initial reactant and a lactone react with a stream comprising n-Butyllithium; and (b) making the stream comprising the first product react with a stream comprising p-toluenesulfonic acid (PTSA) to produce a second product.COPYRIGHT KIPO 2020

Industrial preparation method for empagliflozin

The invention discloses an industrial preparation method for empagliflozin. Specifically, the invention relates to a preparation method for empagliflozin as shown in formula as defined in the specification, i.e., (1S)-1,5-dehydro-1-(4-chloro-3{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}pheyl)-D-glucitol, and an intermediate prepared by using the method. The preparation method for empagliflozin in the invention is stable in process, good in reproducibility and suitable for large-scale production.

COMPLEX OF SGLT2 INHIBITOR AND PROCESS FOR PREPARATION THEREOF

The present invention relates to a crystalline Form A of complex of Empagliflozin with L-Proline and process for preparation thereof. The present invention further relates to a method of preparing pure crystalline Empagliflozin via formation of the said complex.

Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein

The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.