α-methyl-α-(1-methylethyl)-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol

Base Information

• Chemical Name: α-methyl-α-(1-methylethyl)-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol
• CAS No.: 125251-00-5
• Molecular Formula: C₂₃H₃₇NO₂
• Molecular Weight: 359.552
• Mol file: 125251-00-5.mol

Synonyms:

Chemical Property of α-methyl-α-(1-methylethyl)-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-methyl-α-(1-methylethyl)-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol

There total 3 articles about α-methyl-α-(1-methylethyl)-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone (115156-70-2) + isopropylmagnesium chloride (1068-55-9) → α-methyl-α-(1-methylethyl)-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol (125251-00-5) + (S)-2-((2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-3-methyl-butan-2-ol (125355-35-3)

Guidance literature:

In diethyl ether; at 5 ℃; for 5.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00294a026

Reference yield:

methylmagnesium bromide (75-16-1) + 2-methyl-1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>propan-1-one (125250-95-5) → α-methyl-α-(1-methylethyl)-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol (125251-00-5) + (S)-2-((2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-3-methyl-butan-2-ol (125355-35-3)

Guidance literature:

In diethyl ether; at 5 ℃; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00294a026

Reference yield:

(4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazine-2-carboxylic acid methyl ester (115156-68-8,125353-88-0,125353-89-1) → α-methyl-α-(1-methylethyl)-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol (125251-00-5)

Guidance literature:

Multi-step reaction with 2 steps

2: diethyl ether / 5 °C

In diethyl ether;

DOI:10.1021/jo00294a026

upstream raw materials:

1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone

isopropylmagnesium chloride

methylmagnesium bromide

2-methyl-1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>propan-1-one