(S)-2-(2-Hydroxypropyl)-6-methoxybenzonitrile

Base Information

• Chemical Name: (S)-2-(2-Hydroxypropyl)-6-methoxybenzonitrile
• CAS No.: 256526-07-5
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol file: 256526-07-5.mol

Synonyms:

Chemical Property of (S)-2-(2-Hydroxypropyl)-6-methoxybenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-Hydroxypropyl)-6-methoxybenzonitrile

There total 3 articles about (S)-2-(2-Hydroxypropyl)-6-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-6-methyl-benzonitrile (53005-44-0) → (S)-2-(2-Hydroxypropyl)-6-methoxybenzonitrile (256526-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (i-Pr)2NH; BuLi / tetrahydrofuran; hexane

1.2: 72 percent / tetrahydrofuran; hexane

2.1: Candida parapsilosis carbonyl reductase [EC 1.1.1.184]; Candida boidini formate dehydrogenase [EC 1.2.1.2]; sodium formate / NAD(+) / 96 h / pH 7

With n-butyllithium; Candida boidini formate dehydrogenase [EC 1.2.1.2]; Candida parapsilosis carbonyl reductase [EC 1.1.1.184]; sodium formate; diisopropylamine; nicotinamide adenine dinucleotide; In tetrahydrofuran; hexane; 1.1: Metallation / 1.2: Acylation / 2.1: Reduction;

DOI:10.1055/s-1999-3629

Reference yield:

2-methoxy-6-methylbenzeneamine (50868-73-0) → (S)-2-(2-Hydroxypropyl)-6-methoxybenzonitrile (256526-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 63 percent / NaNO₂

2.1: (i-Pr)2NH; BuLi / tetrahydrofuran; hexane

2.2: 72 percent / tetrahydrofuran; hexane

3.1: Candida parapsilosis carbonyl reductase [EC 1.1.1.184]; Candida boidini formate dehydrogenase [EC 1.2.1.2]; sodium formate / NAD(+) / 96 h / pH 7

With n-butyllithium; Candida boidini formate dehydrogenase [EC 1.2.1.2]; Candida parapsilosis carbonyl reductase [EC 1.1.1.184]; sodium formate; diisopropylamine; sodium nitrite; nicotinamide adenine dinucleotide; In tetrahydrofuran; hexane; 1.1: Diazotization / 1.2: Substitution / 2.1: Metallation / 2.2: Acylation / 3.1: Reduction;

DOI:10.1055/s-1999-3629

Reference yield:

2-Methoxy-6-(2-oxopropyl)benzonitrile (256526-06-4) → (S)-2-(2-Hydroxypropyl)-6-methoxybenzonitrile (256526-07-5)

Guidance literature:

With Candida boidini formate dehydrogenase [EC 1.2.1.2]; Candida parapsilosis carbonyl reductase [EC 1.1.1.184]; sodium formate; nicotinamide adenine dinucleotide; for 96h; pH=7;

DOI:10.1055/s-1999-3629

upstream raw materials:

2-Methoxy-6-(2-oxopropyl)benzonitrile

2-methoxy-6-methyl-benzonitrile

2-methoxy-6-methylbenzeneamine