(1R,1'S)--N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine

Base Information

Chemical Name:(1R,1'S)--N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine
CAS No.:126927-13-7
Molecular Formula:C₂₆H₃₁NO₂
Molecular Weight:389.538
Hs Code.:

(1R,1'S)-<N-2'-(phenylmethoxy)-1'-phenylethyl>-N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,1'S)--N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine

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Technology Process of (1R,1'S)--N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine

There total 7 articles about (1R,1'S)--N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 677-22-5
tert-butylmagnesium chloride

: 127001-25-6
(-)-(S)-N-benzylidene-2-(phenylmethoxy)-1-phenylethanamine N-oxide

: 126927-13-7
(1R,1'S)--N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine

: 126948-80-9
(1S,1'S)--N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine

Guidance literature:: In diethyl ether; at 25 ℃; for 1.5h;
DOI:10.1021/jo00298a019

Reference yield:

: 2935-35-5
(S)-2-phenylglycine

: 126927-13-7
(1R,1'S)--N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / SOCl₂ / 10 h / Ambient temperature

2: 83 percent / NaBH₄ / aq. ethanol / 1) RT, 9h, b) 5.5h, reflux, c) RT, 8h

3: 73 percent / KH

5: 87 percent / NaOH

6: 93 percent / Na₂SO₄ / CH₂Cl₂

7: 2 percent / diethyl ether / 1.5 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; thionyl chloride; potassium hydride; sodium sulfate; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00298a019

Reference yield:

: 20989-17-7
(2S)-2-phenylglycinol

: 126927-13-7
(1R,1'S)--N-hydroxy-2,2-dimethyl-1-phenyl-1-propanamine

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / KH

3: 87 percent / NaOH

4: 93 percent / Na₂SO₄ / CH₂Cl₂

5: 2 percent / diethyl ether / 1.5 h / 25 °C

With sodium hydroxide; potassium hydride; sodium sulfate; In diethyl ether; dichloromethane;
DOI:10.1021/jo00298a019