(4aR,14aS)-Dodecahydro-5,8,11,14-tetraoxa-benzocyclododecene

Base Information

• Chemical Name: (4aR,14aS)-Dodecahydro-5,8,11,14-tetraoxa-benzocyclododecene
• CAS No.: 125279-92-7
• Molecular Formula: C₁₂H₂₂O₄
• Molecular Weight: 230.304
• Mol file: 125279-92-7.mol

Synonyms:

Chemical Property of (4aR,14aS)-Dodecahydro-5,8,11,14-tetraoxa-benzocyclododecene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aR,14aS)-Dodecahydro-5,8,11,14-tetraoxa-benzocyclododecene

There total 5 articles about (4aR,14aS)-Dodecahydro-5,8,11,14-tetraoxa-benzocyclododecene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

benzo-12-crown-4 (14174-08-4) → (4aR,14aS)-Dodecahydro-5,8,11,14-tetraoxa-benzocyclododecene (17454-42-1,125279-92-7,125356-38-9)

Guidance literature:

With hydrogen; (PAA)6RhCl; In water; isopropyl alcohol; under 760 Torr;

Reference yield: 30.0%

1,2-cyclohexano-3,6,9-trioxaundecane-1,11-diol (74262-29-6) → Cyclohexano-12-crown-4 (17454-42-1,125279-92-7,125356-38-9)

Guidance literature:

With sodium hydroxide; p-toluenesulfonyl chloride; In 1,4-dioxane; at 60 ℃; for 20h;

DOI:10.1021/jo01314a030

Reference yield:

cyclohexane-1,2-epoxide (286-20-4) → Cyclohexano-12-crown-4 (17454-42-1,125279-92-7,125356-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH (oil-suspended) / 1.) dioxane, 20 deg C, 2.) 24 h, reflux

2: 30 percent / NaOH, p-toluenesulfonyl chloride / dioxane / 20 h / 60 °C

With sodium hydroxide; sodium hydride; p-toluenesulfonyl chloride; In 1,4-dioxane;

DOI:10.1021/jo01314a030

upstream raw materials:

1,2-cyclohexano-3,6,9-trioxaundecane-1,11-diol

cyclohexane-1,2-epoxide

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

benzo-12-crown-4