14174-08-4Relevant articles and documents
Two new "onium" fluorosilicates, the products of interaction of fluorosilicic acid with 12-membered macrocycles: Structures and spectroscopic properties
Gelmboldt, Vladimir O.,Ganin, Eduard V.,Fonari, Marina S.,Simonov, Yurii A.,Koroeva, Larisa V.,Ennan, Alim A.,Basok, Stepan S.,Shova, Sergiu,Kaehlig, Hanspeter,Arion, Vladimir B.,Keppler, Bernhard K.
, p. 2915 - 2924 (2007)
Two novel compounds, (L1H)2[SiF6] ·2H2O (1) and (L2H)2[SiF 5(H2O)]2·3H2O (2), resulting from the reactions of H2SiF6 with 4′-aminobenzo-12- crown-4 (L1) and monoaza-12-crown-4 (L2), respectively, were studied by X-ray diffraction and characterised by IR and 19F NMR spectroscopic methods. Both complexes have ionic structures due to the proton transfer from the fluorosilicic acid to the primary amine group in L1 and secondary amine group incorporated into the macrocycle L2. The structure of 1 is composed of [SiF6]2- centrosymmetric anions, N-protonated cations (L1H)+, and two water molecules, all components being bound in the layer through a system of NH...F, NH...O and OH...F hydrogen bonds. The [SiF 6]2- anions and water molecules are assembled into inorganic negatively-charged layers via OH...F hydrogen bonds. The structure of 2 is a rare example of stabilisation of the complex anion [SiF 5(H2O)]-, the labile product of hydrolytic transformations of the [SiF6]2- anion in an aqueous solution. The components of 2, i.e., [SiF5(H2O)] -, (L2H)+, and water molecules, are linked by a system of NH...F, NH...O, OH...F, OH...O hydrogen bonds. In a way similar to 1, the [SiF5(H2O)]- anions and water molecules in 2 are combined into an inorganic negatively-charged layer through OH...F and OH...O interactions. The Royal Society of Chemistry.
Photoresponsive Crown Ethers. 4. Influence of Alkali Metal Cations on Photoisomerization and Thermal Izomerization of Azobis(benzocrown ether)s
Shinkai, Seiji,Ogawa, Toshiyuki,Kusano, Yumiko,Manabe, Osamu,Kikukawa, Kiyoshi,et al.
, p. 1960 - 1967 (1982)
Five photoresponsive azobis(benzocrown ether)s 1(4,4), 1(5,5), 1(6,6), 2(5,5) and 2(6,6), were synthesized, where numbers in parentheses denote the number of oxygens in benzocrown ethers, and crown series 2 have two tert-butyl groups in the 2 and 2' position of the azo linkage.We have found that (i) in the presence of alkali metal cations, the concentration of cis isomers (cis percent) under the photostationary state is enhanced and the rate of thermal cis-to-trans isomerization (k) is supressed, the optima cis-1(5,5) and cis-1(6,6) being observed for Rb+ and Cs+, respectively, (ii) Rb+ and Cs+ are extracted most efficiently from an aqueous solution to an organic phase (o-dichlorobenzene) with cis-1(5,5) and cis-1(6,6), respectively, (iii) cis percent and k of 2(5,5) and 2(6,6) are affected by alkyli metal cations smaller than those of corresponding 1(5,5) and 1(6,6), and (iv) cis percent and k of 1(4,4) are less affected by added alkali metal cations and the extractability is very low.The increase in cis percent and the supression of the thermal isomerization rate are rationalized in terms of the "tying effect" of complexed cations requiring the additional energy to disrupt the crown-cation interaction.The correlation of the extractability with cis percent and k implies that alkali metal cations are extracted under photoirradiation as intramolecular 1:2 cation/crown complexes and the ion selectivity is associated with the fitness between the ion size and the size of the spatial cavity provided by two crown ethers of cis form.The ion selectivity suggests (i) the cavity size of cis-1(6,6) is greater than that of cis-(5,5) and (ii) the cavity sizes of crown series 2 are smaller than those of crown series 1 probably owing to the steric repulsion of the tert-butyl groups.Hence, the ion selectivity in the photocontrolled solvent extraction is effected by the crown ring size and the steric crowding around the azo linkage.
Fingolimod derivatives containing crown ether and bis (2 - methoxyethoxy) structure (by machine translation)
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Paragraph 0023; 0033-0040, (2020/06/20)
The invention synthesizes a series of fingolimod derivatives containing crown ether or bis (2 - methoxyethoxy) structure by modifying the structure of the immunosuppressant fingolimod for treating multiple sclerosis in the market. The hypoglycemic effect of the target compound was evaluated by in vivo animal experiments. The results show that the compounds including 1c - 1e, Ic-Ie have a certain effect of reducing blood sugar and have application prospects in the preparation of medicines for treating diabetes. (by machine translation)
SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF
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Paragraph 00232, (2019/03/17)
The invention provide novel pyrimidine derivatives and analogs having inhibitory activities towards certain tyrosine kinases, e.g., Bruton's tyrosine kinase (Btk) and/or Focal adhesion kinase (FAK), extracellular signal-regulated kinase (ERK), pharmaceutical compositions thereof, and methods of treatment, reduction or prevention of certain diseases or conditions mediated by such by tyrosine kinases, e.g., cancers, tumors, fibrosis, inflammatory diseases, autoimmune diseases, diabetes, or immunologically mediated diseases.
