1,2-trans-1-(p-hydroxyphenyl)-2-benzyl-7-methoxy-benzosuberan

Base Information

• Chemical Name: 1,2-trans-1-(p-hydroxyphenyl)-2-benzyl-7-methoxy-benzosuberan
• CAS No.: 77607-61-5
• Molecular Formula: C₂₅H₂₆O₂
• Molecular Weight: 358.48
• Mol file: 77607-61-5.mol

Synonyms:

Chemical Property of 1,2-trans-1-(p-hydroxyphenyl)-2-benzyl-7-methoxy-benzosuberan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-trans-1-(p-hydroxyphenyl)-2-benzyl-7-methoxy-benzosuberan

There total 8 articles about 1,2-trans-1-(p-hydroxyphenyl)-2-benzyl-7-methoxy-benzosuberan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one (6500-65-8) → 1,2-trans-1-(p-hydroxyphenyl)-2-benzyl-7-methoxy-benzosuberan (77607-61-5,104077-33-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / KOH / methanol / 1.) 10 deg C, 30 min, 2.) room temperature, 4 h

2: 100 percent / hydrogen / 10 percent Pd-C / ethyl acetate / 760 Torr / Ambient temperature

3: 99 percent / KBH₄ / methanol / 4 h / Ambient temperature

4: 51 percent / HCl gas / ethanol / 168 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; potassium borohydride; hydrogen; palladium on activated charcoal; In methanol; ethanol; ethyl acetate;

Reference yield:

5-(3'-methoxyphenyl)pentanoic acid (6500-64-7) → 1,2-trans-1-(p-hydroxyphenyl)-2-benzyl-7-methoxy-benzosuberan (77607-61-5,104077-33-0)

Guidance literature:

Multi-step reaction with 6 steps

1: PCl₅ / benzene / 0.5 h / Heating

2: SnCl₄ / benzene / 24 h / Ambient temperature

3: 77 percent / KOH / methanol / 1.) 10 deg C, 30 min, 2.) room temperature, 4 h

4: 100 percent / hydrogen / 10 percent Pd-C / ethyl acetate / 760 Torr / Ambient temperature

5: 99 percent / KBH₄ / methanol / 4 h / Ambient temperature

6: 51 percent / HCl gas / ethanol / 168 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; potassium borohydride; phosphorus pentachloride; hydrogen; tin(IV) chloride; palladium on activated charcoal; In methanol; ethanol; ethyl acetate; benzene;

Reference yield:

5-(m-methoxyphenyl)penta-2,4-dienoic acid (6500-63-6) → 1,2-trans-1-(p-hydroxyphenyl)-2-benzyl-7-methoxy-benzosuberan (77607-61-5,104077-33-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 23 g / hydrogen / 10percent Pd-C / ethanol / 760 Torr / Ambient temperature

2: PCl₅ / benzene / 0.5 h / Heating

3: SnCl₄ / benzene / 24 h / Ambient temperature

4: 77 percent / KOH / methanol / 1.) 10 deg C, 30 min, 2.) room temperature, 4 h

5: 100 percent / hydrogen / 10 percent Pd-C / ethyl acetate / 760 Torr / Ambient temperature

6: 99 percent / KBH₄ / methanol / 4 h / Ambient temperature

7: 51 percent / HCl gas / ethanol / 168 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; potassium borohydride; phosphorus pentachloride; hydrogen; tin(IV) chloride; palladium on activated charcoal; In methanol; ethanol; ethyl acetate; benzene;

upstream raw materials:

2-benzyl-7-methoxy-1-benzosuberol

phenol

2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one

5-(3'-methoxyphenyl)pentanoic acid

Downstream raw materials:

1,2-trans-1-(p-acetoxyphenyl)-2-benzyl-7-methoxy-benzosuberan