C₂₁H₂₀⁽³⁾HF₃N₂O

Base Information

Chemical Name:C₂₁H₂₀⁽³⁾HF₃N₂O
CAS No.:127666-70-0
Molecular Formula:C₂₁H₂₁F₃N₂O
Molecular Weight:376.398
Hs Code.:

C<sub>21</sub>H<sub>20</sub><sup>(3)</sup>HF<sub>3</sub>N<sub>2</sub>O

Synonyms:

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Chemical Property of C₂₁H₂₀⁽³⁾HF₃N₂O

Chemical Property:

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Technology Process of C₂₁H₂₀⁽³⁾HF₃N₂O

There total 29 articles about C₂₁H₂₀⁽³⁾HF₃N₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5757-66-4
4-bromo-2,6-dimethylbenzonitrile

: 127666-70-0
C₂₁H₂₀⁽³⁾HF₃N₂O

Guidance literature:: Multi-step reaction with 10 steps

1: 88 percent / diisobutylaluminum hydride (DIBAL) / benzene; hexane / 1 h / Ambient temperature

2: 88 percent / LiAlH₄ / tetrahydrofuran / 1 h / 4 °C

3: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

5: Ag₂O / diethyl ether

6: HCl / methanol

7: 1.2 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

8: 1) 1 M lithium bis(trimethylsilyl)amide / 1) THF, -78 deg C - 4 deg C, 2) THF, 20 min

9: 1) NaB⁽³⁾H₄, 2) MnO₂ / 1) THF, H₂O, 2) CH₂Cl₂

10: silica gel / cyclohexane / 0.13 h / Irradiation

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; sodium boron [ 3H]hydride; silica gel; diisobutylaluminium hydride; pyridinium chlorochromate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00303a038

Reference yield:

: 5757-66-4
4-bromo-2,6-dimethylbenzonitrile

: 127666-70-0
C₂₁H₂₀⁽³⁾HF₃N₂O

Guidance literature:: Multi-step reaction with 10 steps

1: 88 percent / diisobutylaluminum hydride (DIBAL) / benzene; hexane / 1 h / Ambient temperature

2: 88 percent / LiAlH₄ / tetrahydrofuran / 1 h / 4 °C

3: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

5: Ag₂O / diethyl ether

6: HCl / methanol

7: 1.2 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

8: 1) 1 M lithium bis(trimethylsilyl)amide / 1) THF, -78 deg C - 4 deg C, 2) THF, 20 min

9: 1) NaB⁽³⁾H₄, 2) MnO₂ / 1) THF, H₂O, 2) CH₂Cl₂

10: silica gel / cyclohexane / 0.13 h / Irradiation

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; sodium boron [ 3H]hydride; silica gel; diisobutylaluminium hydride; pyridinium chlorochromate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; cyclohexane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00303a038

Reference yield:

: 5769-33-5
2,6-dimethyl-4-bromobenzaldehyde

: 127666-70-0
C₂₁H₂₀⁽³⁾HF₃N₂O

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / LiAlH₄ / tetrahydrofuran / 1 h / 4 °C

2: 85 percent / imidazole / dimethylformamide / 15 h / Ambient temperature

4: Ag₂O / diethyl ether

5: HCl / methanol

6: 1.2 g / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

7: 1) 1 M lithium bis(trimethylsilyl)amide / 1) THF, -78 deg C - 4 deg C, 2) THF, 20 min

8: 1) NaB⁽³⁾H₄, 2) MnO₂ / 1) THF, H₂O, 2) CH₂Cl₂

9: silica gel / cyclohexane / 0.13 h / Irradiation

With 1H-imidazole; hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; sodium boron [ 3H]hydride; silica gel; pyridinium chlorochromate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jo00303a038