{3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(R)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(R)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzyl}-carbamic acid tert-butyl ester
CAS No.:195717-78-3
Molecular Formula:C₄₅H₆₇N₅O₄Si
Molecular Weight:770.144
Hs Code.:

{3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(R)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzyl}-carbamic acid tert-butyl ester

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Chemical Property of {3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(R)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzyl}-carbamic acid tert-butyl ester

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Technology Process of {3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(R)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzyl}-carbamic acid tert-butyl ester

There total 12 articles about {3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(R)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1212-29-9
1,3-dicyclohexylthiourea

: 195717-75-0
[4-((R)-2-Amino-3-naphthalen-2-yl-propionylamino)-3-(tert-butyl-dimethyl-silanyloxymethyl)-benzyl]-carbamic acid tert-butyl ester

: 195717-78-3
{3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(R)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; mercury dichloride; In acetonitrile; at 80 ℃;
DOI:10.1016/S0960-894X(97)00328-4

Reference yield:

: 3113-72-2
5-methyl-2-nitrobenzoic acid

: 195717-78-3
{3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(R)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: hydrogenchloride / 65 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C

3: Bu₃P⁺(C₁₆H₃₃)Br^- / toluene / 60 °C

4: hydrogenchloride; tin(ll) chloride / tetrahydrofuran

5: hydrazine hydrate / methanol

6: tetrahydrofuran

7: diisobutylaluminium hydride / dichloromethane

8: 1H-imidazole / dichloromethane

9: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide

10: piperidine / N,N-dimethyl-formamide

11: triethylamine; mercury dichloride / acetonitrile / 80 °C

With piperidine; 1H-imidazole; hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Bu₃P⁺(C₁₆H₃₃)Br^-; diisobutylaluminium hydride; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; mercury dichloride; tin(ll) chloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0960-894X(97)00328-4

Reference yield:

: 20587-30-8
5-methyl-2-nitro-benzoic acid methyl ester

: 195717-78-3
{3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(R)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C

2: Bu₃P⁺(C₁₆H₃₃)Br^- / toluene / 60 °C

3: hydrogenchloride; tin(ll) chloride / tetrahydrofuran

4: hydrazine hydrate / methanol

5: tetrahydrofuran

6: diisobutylaluminium hydride / dichloromethane

7: 1H-imidazole / dichloromethane

8: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide

9: piperidine / N,N-dimethyl-formamide

10: triethylamine; mercury dichloride / acetonitrile / 80 °C

With piperidine; 1H-imidazole; hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Bu₃P⁺(C₁₆H₃₃)Br^-; diisobutylaluminium hydride; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; mercury dichloride; tin(ll) chloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0960-894X(97)00328-4