Technology Process of cis, trans-1-hydroxymethyl-2,3-diphenylcyclopropane
There total 6 articles about cis, trans-1-hydroxymethyl-2,3-diphenylcyclopropane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 25 ℃;
for 16h;
Inert atmosphere;
DOI:10.1039/c9ob00359b
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1H-imidazole / dichloromethane / 18 h / 20 °C / Inert atmosphere
2.1: diethylzinc; trifluoroacetic acid; tert-butyl methyl ether / 1,2-dichloro-ethane / 0.5 h / -40 °C / Inert atmosphere
2.2: 20 h / -40 - 20 °C / Inert atmosphere
3.1: bis(dibenzylideneacetone)-palladium(0); tricyclohexylphosphine; potassium hydroxide / toluene; water / 20 h / Heating; Inert atmosphere; Sealed tube
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.83 h / 0 - 20 °C / Inert atmosphere
With
1H-imidazole; tert-butyl methyl ether; tetrabutyl ammonium fluoride; diethylzinc; trifluoroacetic acid; potassium hydroxide; bis(dibenzylideneacetone)-palladium(0); tricyclohexylphosphine;
In
tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; toluene;
2.2: |Simmons-Smith Cyclopropanation / 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jacs.6b09090
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium hydroxide;
In
tetrahydrofuran; water;
at 65 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/ja906033g
