4,4-bis(Diethyl)phosphono butanoic acid

Base Information

• Chemical Name: 4,4-bis(Diethyl)phosphono butanoic acid
• CAS No.: 136496-88-3
• Molecular Formula: C12H26O8P2
• Molecular Weight: 280.29800
• Mol file: 136496-88-3.mol

Synonyms:Butanoic acid,4,4-bis(diethoxyphosphinyl);4,4-bis(diethoxyphosphinoyl)butyric acid;acide 4,4-bis(diethylphosphono)butanoique;tetraethyl 3-carboxypropylene-1,1-bisphosphonate;tetraethyl 1-carboxypropylene-3,3-bisphosphonate;4,4-bis(diethylphosphono)butanoic acid;

Chemical Property of 4,4-bis(Diethyl)phosphono butanoic acid

Chemical Property:

• PSA: 104.64000
• LogP: 2.71580

Purity/Quality:

99% ^*data from raw suppliers

4,4-BIS(DIETHYL)PHOSPHONO BUTANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-bis(Diethyl)phosphono butanoic acid

There total 9 articles about 4,4-bis(Diethyl)phosphono butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tetraethyl 3,3-bis(phosphono)propyliden bis(carboxylic acid) (184225-13-6) → tetraethyl 3-carboxypropylene-1,1-bisphosphonate (136496-88-3)

Guidance literature:

at 130 ℃; for 3h;

DOI:10.1016/S0040-4020(00)01164-9

Reference yield: 99.0%

tetraethyl 3-(t-butoxycarbonyl)propylene-1,1-bisphosphonate (925684-59-9) → tetraethyl 3-carboxypropylene-1,1-bisphosphonate (136496-88-3)

Guidance literature:

With trifluoroacetic acid; for 0.25h;

Reference yield: 98.0%

tetraethyl 4-hydroxybutylene-1,1-bisphosphonate (150250-34-3) → tetraethyl 3-carboxypropylene-1,1-bisphosphonate (136496-88-3)

Guidance literature:

With sodium hydroxide; disodium hydrogenphosphate; sodium dihydrogenphosphate; NaClO₂; sodium sulfate; cyfluthrin; In diethyl ether; water; acetonitrile;

upstream raw materials:

tetraethyl 3,3-bis(phosphono)propyliden bis(carboxylic acid)

Tetraethyl methylenediphosphonate

1,1-bis(diethylphosphono)ethylene

ethyl 4,4-bis(diethoxyphosphoryl)-2-ethoxycarbonylbutyrate

Refernces

• 1、 -. "PHOSPHONATED GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS". . . Retrieved 2010/05/13.
• 2、 -. "Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections". . . Retrieved 2008/12/09.