2-[4-[2-[4-(6-Aminopyridin-2-yl)phenyl]ethyl]piperazin-1-yl]-1-phenylethanone

Base Information

• Chemical Name: 2-[4-[2-[4-(6-Aminopyridin-2-yl)phenyl]ethyl]piperazin-1-yl]-1-phenylethanone
• CAS No.: 198211-96-0
• Molecular Formula: C₂₅H₂₈N₄O
• Molecular Weight: 400.524
• Mol file: 198211-96-0.mol

Synonyms:

Chemical Property of 2-[4-[2-[4-(6-Aminopyridin-2-yl)phenyl]ethyl]piperazin-1-yl]-1-phenylethanone

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-[2-[4-(6-Aminopyridin-2-yl)phenyl]ethyl]piperazin-1-yl]-1-phenylethanone

There total 6 articles about 2-[4-[2-[4-(6-Aminopyridin-2-yl)phenyl]ethyl]piperazin-1-yl]-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

→ 2-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-piperazin-1-yl)-1-phenyl-ethanone (198211-96-0)

Guidance literature:

Reference yield:

4-(2-chloroethyl)iodobenzene (75067-07-1) → 2-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-piperazin-1-yl)-1-phenyl-ethanone (198211-96-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: nBuLi; ZnCl₂

1.2: Pd⁰

2.1: aq. NH₂OH*HCl / ethanol

3.1: NaI / dimethylformamide

4.1: TFA / CH₂Cl₂

With n-butyllithium; hydroxylamine hydrochloride; trifluoroacetic acid; sodium iodide; zinc(II) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Condensation / 2.1: Hydrolysis / 3.1: Substitution / 4.1: Hydrolysis / 5.1: Condensation;

DOI:10.1016/S0960-894X(99)00432-1

Reference yield:

6-[4-(2-chloro-ethyl)-phenyl]-pyridin-2-ylamine (198210-90-1) → 2-(4-{2-[4-(6-Amino-pyridin-2-yl)-phenyl]-ethyl}-piperazin-1-yl)-1-phenyl-ethanone (198211-96-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaI / dimethylformamide

2: TFA / CH₂Cl₂

With trifluoroacetic acid; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Condensation;

DOI:10.1016/S0960-894X(99)00432-1

upstream raw materials:

α-bromoacetophenone

6-[4-(2-piperazin-1-yl-ethyl)-phenyl]-pyridin-2-ylamine

4-(2-chloroethyl)iodobenzene

6-[4-(2-chloro-ethyl)-phenyl]-pyridin-2-ylamine

Refernces

• 1、 -. "PHARMACEUTICAL USES FOR NOS INHIBITORS". . . Retrieved 2008/06/13.
• 2、 Lowe III, John A.,Qian, Weimin,Volkmann, Robert A.,Heck, Steven,Nowakowski, Jolanta,Nelson, Robert,Nolan, Charles,Liston, Dane,Ward, Karen,Zorn, Stevin,Johnson, Celeste,Vanase, Michelle,Faraci, W. Stephen,Verdries, Kimberly A.,Baxter, James,Doran, Shawn,Sanders, Martin,Ashton, Mike,Whittle, Peter,Stefaniak, Mark. "A new class of selective and potent inhibitors of neuronal nitric oxide synthase". . p. 2569 - 2572. Retrieved 2007/10/03.