C₆₉H₆₇Cl₂N₄O₁₄PS

Base Information

• Chemical Name: C₆₉H₆₇Cl₂N₄O₁₄PS
• CAS No.: 153413-68-4
• Molecular Formula: C₆₉H₆₇Cl₂N₄O₁₄PS
• Molecular Weight: 1310.26
• Mol file: 153413-68-4.mol

Synonyms:

Chemical Property of C₆₉H₆₇Cl₂N₄O₁₄PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₉H₆₇Cl₂N₄O₁₄PS

There total 3 articles about C₆₉H₆₇Cl₂N₄O₁₄PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichlorobenzyl mercaptan (59293-67-3) + C68H66N5O17P (153413-67-3) → C69H67Cl2N4O14PS (153413-68-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.00833333h;

DOI:10.1016/0040-4039(93)85068-8

Reference yield:

O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(4-nitrophenyl) N,N-diisopropylphosphoramidite (153413-66-2,162681-43-8,162681-44-9) → C69H67Cl2N4O14PS (153413-68-4)

Guidance literature:

Multi-step reaction with 3 steps

1: DBU / acetonitrile / 0.02 h / 20 °C

2: tetrazole / acetonitrile / 0.25 h / 20 °C

3: DBU / acetonitrile / 0.01 h / 20 °C

With 1H-tetrazole; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1016/0040-4039(93)85068-8

Reference yield:

O-[5'-O-(4,4-dimethoxytrityl)thymidin-3-yl]-O-[3'-O-(4,4-dimethoxytrityl)thymidin-5'-yl]N,N-diisopropylphosphoramidite (153454-33-2) → C69H67Cl2N4O14PS (153413-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrazole / acetonitrile / 0.25 h / 20 °C

2: DBU / acetonitrile / 0.01 h / 20 °C

With 1H-tetrazole; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1016/0040-4039(93)85068-8

upstream raw materials:

2,4-dichlorobenzyl mercaptan

C₆₈H₆₆N₅O₁₇P

O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(4-nitrophenyl) N,N-diisopropylphosphoramidite

O-[5'-O-(4,4-dimethoxytrityl)thymidin-3-yl]-O-[3'-O-(4,4-dimethoxytrityl)thymidin-5'-yl]N,N-diisopropylphosphoramidite

Downstream raw materials:

C₆₉H₆₇Cl₂N₄O₁₄PS₂

S-(2,4-dichlorobenzyl)-5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 3'-O-(4,4'-dimethoxytrityl)thymidin-5-yl phosphoroselenothioate