2-(2,4,6-trimethoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Base Information

• Chemical Name: 2-(2,4,6-trimethoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane
• CAS No.: 335343-08-3
• Molecular Formula: C₁₄H₂₁BO₅
• Molecular Weight: 280.129
• Mol file: 335343-08-3.mol

Synonyms:

Chemical Property of 2-(2,4,6-trimethoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Chemical Property:

• Melting Point: 105-109?°C
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,5-Dimethyl-2-(2,4,6-trimethoxyphenyl)-1,3,2-dioxaborinane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,4,6-trimethoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

There total 2 articles about 2-(2,4,6-trimethoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2,4,6-trimethoxyphenyl)boronic acid (135159-25-0) + 2,2-Dimethyl-1,3-propanediol (126-30-7) → 5,5-dimethyl-2-(2,4,6-trimethoxyphenyl)-1,3,2-dioxaborinane (335343-08-3)

Guidance literature:

In tetrahydrofuran; for 9h; Heating;

DOI:10.1016/S0040-4020(00)00928-5

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) → 5,5-dimethyl-2-(2,4,6-trimethoxyphenyl)-1,3,2-dioxaborinane (335343-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; TMEDA / diethyl ether; hexane / 0.33 h / -5 °C

1.2: trimethyl borate / diethyl ether; hexane; tetrahydrofuran / 16 h / -78 - 20 °C

1.3: 60 percent / aq. HCl / pH 5 - 6 / cooling

2.1: 75 percent / tetrahydrofuran / 9 h / Heating

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; diethyl ether; hexane; 1.1: Metallation / 1.2: boronation / 1.3: Hydrolysis / 2.1: Esterification;

DOI:10.1016/S0040-4020(00)00928-5

upstream raw materials:

(2,4,6-trimethoxyphenyl)boronic acid

2,2-Dimethyl-1,3-propanediol

1,2,3-trimethoxybenzene

Refernces