[S-(R,R)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Base Information

Chemical Name:[S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester
CAS No.:101250-67-3
Molecular Formula:C₂₅H₄₀N₂O₄S
Molecular Weight:464.67
Hs Code.:

[S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

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Chemical Property of [S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

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Technology Process of [S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

There total 4 articles about [S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 101250-67-3
[S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Guidance literature:

Reference yield:

: 23852-57-5
(S)-2-(2-Methylpropyl)-aziridine

: 101250-67-3
[S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / H₂S / ethanol / -78 - 25 °C

2: 43 percent / NH₃ liquid

3: 1.) 5A molecular sieves, 2.) bromocresol, NaCNBH₃, HCl gas / 1.) THF, overnight, 2.) EtOH, 25 deg C, 2 d

With hydrogenchloride; 5A molecular sieve; 2-bromo-6-methylphenol; hydrogen sulfide; ammonia; sodium cyanoborohydride; In ethanol;
DOI:10.1021/jm00156a012

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 101250-67-3
[S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / NH₃ liquid

2: 1.) 5A molecular sieves, 2.) bromocresol, NaCNBH₃, HCl gas / 1.) THF, overnight, 2.) EtOH, 25 deg C, 2 d

With hydrogenchloride; 5A molecular sieve; 2-bromo-6-methylphenol; ammonia; sodium cyanoborohydride;
DOI:10.1021/jm00156a012