5'-t-butoxycarbonyl-5',6'-dihydro-2,6-dioxo-1-phenylspiropyrrolo<1,2-a><1,4>benzodiazepine>

Base Information

Chemical Name:5'-t-butoxycarbonyl-5',6'-dihydro-2,6-dioxo-1-phenylspiropyrrolo<1,2-a><1,4>benzodiazepine>
CAS No.:154227-88-0
Molecular Formula:C₂₇H₂₇N₃O₄
Molecular Weight:457.529
Hs Code.:

5'-t-butoxycarbonyl-5',6'-dihydro-2,6-dioxo-1-phenylspiro<piperidine-4,4'-<4H>pyrrolo<1,2-a><1,4>benzodiazepine>

Synonyms:

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Chemical Property of 5'-t-butoxycarbonyl-5',6'-dihydro-2,6-dioxo-1-phenylspiropyrrolo<1,2-a><1,4>benzodiazepine>

Chemical Property:

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Technology Process of 5'-t-butoxycarbonyl-5',6'-dihydro-2,6-dioxo-1-phenylspiropyrrolo<1,2-a><1,4>benzodiazepine>

There total 5 articles about 5'-t-butoxycarbonyl-5',6'-dihydro-2,6-dioxo-1-phenylspiropyrrolo<1,2-a><1,4>benzodiazepine> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 154227-88-0
5'-t-butoxycarbonyl-5',6'-dihydro-2,6-dioxo-1-phenylspiropyrrolo<1,2-a><1,4>benzodiazepine>

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / toluene / 12 h / Heating

2: 61 percent / aq. NaOH / ethanol / 2.5 h / 90 °C

3: 1.) THF, RT, 18 h, 2.) THF, a) RT, 3 h, reflux 4 h

With sodium hydroxide; In ethanol; toluene;
DOI:10.1002/jhet.5570300409

Reference yield:

: 33265-72-4
1-(2-aminomethylphenyl)-1H-pyrroloe hydrochloride

: 154227-88-0
5'-t-butoxycarbonyl-5',6'-dihydro-2,6-dioxo-1-phenylspiropyrrolo<1,2-a><1,4>benzodiazepine>

Guidance literature:: Multi-step reaction with 4 steps

1: 43 percent / maleic acid / ethanol / 6 h / Heating

2: 100 percent / toluene / 12 h / Heating

3: 61 percent / aq. NaOH / ethanol / 2.5 h / 90 °C

4: 1.) THF, RT, 18 h, 2.) THF, a) RT, 3 h, reflux 4 h

With sodium hydroxide; maleic acid; In ethanol; toluene;
DOI:10.1002/jhet.5570300409

Reference yield:

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 154227-88-0
5'-t-butoxycarbonyl-5',6'-dihydro-2,6-dioxo-1-phenylspiropyrrolo<1,2-a><1,4>benzodiazepine>

Guidance literature:: Multi-step reaction with 4 steps

1: 43 percent / maleic acid / ethanol / 6 h / Heating

2: 100 percent / toluene / 12 h / Heating

3: 61 percent / aq. NaOH / ethanol / 2.5 h / 90 °C

4: 1.) THF, RT, 18 h, 2.) THF, a) RT, 3 h, reflux 4 h

With sodium hydroxide; maleic acid; In ethanol; toluene;
DOI:10.1002/jhet.5570300409