(2R,4S)-2--4-isopropenyl-1-methylenecyclohexane

Base Information

• Chemical Name: (2R,4S)-2--4-isopropenyl-1-methylenecyclohexane
• CAS No.: 130860-49-0
• Molecular Formula: C₁₅H₂₂O₄
• Molecular Weight: 266.337
• Mol file: 130860-49-0.mol

Synonyms:

Chemical Property of (2R,4S)-2--4-isopropenyl-1-methylenecyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2R,4S)-2--4-isopropenyl-1-methylenecyclohexane

There total 2 articles about (2R,4S)-2--4-isopropenyl-1-methylenecyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(4-(prop-1-en-2-yl)cyclohex-1-en-1-yl)methyl acetate (15111-96-3,56452-54-1,35907-08-5) + malonic acid dimethyl ester (108-59-8) → (2R,4S)-2--4-isopropenyl-1-methylenecyclohexane (130860-49-0) + (4S)-4-isopropenyl-1-<2',2-bis(methoxycarbonyl)ethyl>cyclohexene (130860-50-3)

Guidance literature:

With BI₄^(1-)*Mo⁽¹⁺⁾; sodium hydride; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) toluene, 100 deg C, 15 min, 2.) toluene, reflux, 48 h;

DOI:10.1021/ja00182a018

Reference yield:

(2R,4S)-4-isopropenyl-1-methylene-2-(phenylsulfonyl)cyclohexane (130860-48-9) + malonic acid dimethyl ester (108-59-8) → (2R,4S)-2--4-isopropenyl-1-methylenecyclohexane (130860-49-0) + (4S)-4-isopropenyl-1-<2',2-bis(methoxycarbonyl)ethyl>cyclohexene (130860-50-3)

Guidance literature:

With tert-butylisonitrile; sodium hydride; molybdenum hexacarbonyl; In toluene; Product distribution; other malonates; other alkylating compounds, catalysts; var. time;

DOI:10.1021/ja00182a018

upstream raw materials:

(S)-(4-(prop-1-en-2-yl)cyclohex-1-en-1-yl)methyl acetate

malonic acid dimethyl ester

(2R,4S)-4-isopropenyl-1-methylene-2-(phenylsulfonyl)cyclohexane