7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin

Base Information

• Chemical Name: 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin
• CAS No.: 137138-18-2
• Molecular Formula: C₁₉H₂₅N₅O₂
• Molecular Weight: 355.44
• Mol file: 137138-18-2.mol

Synonyms:

Chemical Property of 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin

There total 3 articles about 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

7-Acetonyltheophylline (10226-64-9) + 2-amino-1-phenylpropane (60-15-1,156-34-3,51-64-9,300-62-9,17108-96-2,96332-84-2) → 7-((RS)2-((RS)-1-Methyl-2-phenyl-ethylamino)propyl)-theophyllin (137138-18-2,144848-30-6)

Guidance literature:

With hydrogen; sodium sulfate; palladium on activated charcoal; In ethanol; at 60 ℃; for 4h; under 760 Torr;

DOI:10.1002/ardp.19923250913

Reference yield: 35.0%

2-amino-1-phenylpropane (60-15-1,156-34-3,51-64-9,300-62-9,17108-96-2,96332-84-2) + Propoxyphyllintosylat (137138-15-9) → 7-<2-(1-Methyl-2-phenyl-ethylamino)-propyl>-theophyllin (137138-18-2,144848-30-6)

Guidance literature:

at 150 ℃; for 7h;

DOI:10.1002/ardp.2503240904

Reference yield:

proxyphylline (603-00-9,86480-51-5,86540-95-6,86540-96-7) → 7-<2-(1-Methyl-2-phenyl-ethylamino)-propyl>-theophyllin (137138-18-2,144848-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / pyridine / CHCl₃ / 1) -5 deg C, 4 h 2) r.t., 2 h

2: 35 percent / 7 h / 150 °C

With pyridine; In chloroform;

DOI:10.1002/ardp.2503240904

upstream raw materials:

2-amino-1-phenylpropane

Propoxyphyllintosylat

proxyphylline

7-Acetonyltheophylline

Downstream raw materials:

dexamfetamine

l-amphetamine