10226-64-9 Usage
General Description
"1,3-dimethyl-7-(2-oxopropyl)-3,7-dihydro-1H-purine-2,6-dione" is a chemical compound with the molecular formula C11H14N4O3. It is a derivative of purine, which is a heterocyclic organic compound commonly found in nucleic acids and various natural products. 1,3-dimethyl-7-(2-oxopropyl)-3,7-dihydro-1H-purine-2,6-dione is also known as theophylline, a methylxanthine drug that is used as a bronchodilator and in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Theophylline works by relaxing the smooth muscles in the airways, which helps to improve breathing. It also has mild diuretic and central nervous system stimulant effects. In addition to its medical uses, theophylline is also found in small amounts in tea and cocoa, and it is sometimes used as a doping agent in sports.
Check Digit Verification of cas no
The CAS Registry Mumber 10226-64-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,2 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 10226-64:
(7*1)+(6*0)+(5*2)+(4*2)+(3*6)+(2*6)+(1*4)=59
59 % 10 = 9
So 10226-64-9 is a valid CAS Registry Number.
10226-64-9Relevant articles and documents
Potentiation of cADPR-induced Ca2+-release by methylxanthine analogues
Cavallaro, Rosaria A.,Filocamo, Luigi,Galuppi, Annamaria,Galione, Antony,Brufani, Mario,Genazzani, Armando A.
, p. 2527 - 2534 (2007/10/03)
Caffeine and other methylxanthines are known to induce Ca2+-release from intracellular stores via the ryanodine receptor. In the present work, a range of caffeine analogues, in which methyl groups at the 1 and 7 positions were replaced with alkyl chains containing different functional groups (oxo, hydroxyl, propargyl, ester, and acids), were synthesized. These compounds were then screened for their ability to potentiate Ca2+-release induced by cADPR (an endogenous modulator of ryanodine receptors) in sea urchin egg homogenates. Two of the synthesized methylxanthines, 1,3-dimethyl-7-(7- hydroxyoctyl)xanthine (37) and 3-methyl-7-(7-oxooctyl)-1-propargylxanthine (66), were shown to be more potent than caffeine in potentiating cADPR- induced Ca2+-release, while 1,3-dimethyl-7-(5-ethylcarboxypentyl)xanthine (14) was shown to be more efficacious. The development of new methylxanthine analogues may lead to a better understanding of ryanodine receptor function and could possibly provide novel therapeutic agents.