Technology Process of (3S,4R)-4-benzyl-3-methyl-3,4-dihydroisoquinoline
There total 7 articles about (3S,4R)-4-benzyl-3-methyl-3,4-dihydroisoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1R,2S,5R)-2-[1-((3S,4R)-4-Benzyl-3-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol;
With
3 A molecular sieve; sodium acetate; pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 2h;
With
potassium hydroxide;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
DOI:10.1016/S0040-4020(01)00274-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 81 percent / 2 h / 120 °C
2.1: 50 percent / tributyltin hydride; azobis(isobutyronitrile) / benzene / 13 h / Heating
3.1: diethyl ether
4.1: pyridinium chlorochromate; sodium acetate; molecular sieves 3A / CH2Cl2 / 2 h / 20 °C
4.2: potassium hydroxide / methanol; tetrahydrofuran; H2O / 20 °C
With
2,2'-azobis(isobutyronitrile); 3 A molecular sieve; tri-n-butyl-tin hydride; sodium acetate; pyridinium chlorochromate;
In
diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)00274-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 98 percent / CH2Cl2 / 4 h / 20 °C
2.1: 98 percent / sodium borohydride; BF3*Et2O / tetrahydrofuran / 2 h / 20 °C
3.1: 81 percent / 2 h / 120 °C
4.1: 50 percent / tributyltin hydride; azobis(isobutyronitrile) / benzene / 13 h / Heating
5.1: diethyl ether
6.1: pyridinium chlorochromate; sodium acetate; molecular sieves 3A / CH2Cl2 / 2 h / 20 °C
6.2: potassium hydroxide / methanol; tetrahydrofuran; H2O / 20 °C
With
sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); 3 A molecular sieve; boron trifluoride diethyl etherate; tri-n-butyl-tin hydride; sodium acetate; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)00274-5
![(1R,2S,5R)-2-[1-((3S,4R)-4-Benzyl-3-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol](/Databaselist/images/loading.webp)
