N--O-trimethylsilylhydroxylamine

Base Information

• Chemical Name: N--O-trimethylsilylhydroxylamine
• CAS No.: 140458-24-8
• Molecular Formula: C₁₇H₂₄NO₂PSi
• Molecular Weight: 333.442
• Mol file: 140458-24-8.mol

Synonyms:

Chemical Property of N--O-trimethylsilylhydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N--O-trimethylsilylhydroxylamine

There total 6 articles about N--O-trimethylsilylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N,O-bis(trimethylsilyl)hydroxylamine (22737-37-7) + α-methylbenzyl(phenyl)phosphinic chloride (140458-23-7) → N--O-trimethylsilylhydroxylamine (140458-24-8,140458-25-9)

Guidance literature:

In dichloromethane; at 35 ℃; for 24h;

DOI:10.1039/P19940003261

Reference yield:

(1-methyl-1-phenylethyl)(phenyl)phosphinic acid ethyl ester (461003-63-4) → N--O-trimethylsilylhydroxylamine (140458-24-8,140458-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrochloric acid / H₂O

1.2: SOCl₂

2.1: CH₂Cl₂ / 18 h / 0 - 20 °C

With hydrogenchloride; In dichloromethane; water;

DOI:10.1021/jo0202839

Reference yield:

(1-methyl-1-phenylethyl)(phenyl)phosphinic acid (461003-64-5) → N--O-trimethylsilylhydroxylamine (140458-24-8,140458-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: CH₂Cl₂ / 18 h / 0 - 20 °C

With thionyl chloride; In dichloromethane;

DOI:10.1021/jo0202839

upstream raw materials:

N,O-bis(trimethylsilyl)hydroxylamine

α-methylbenzyl(phenyl)phosphinic chloride

(1-methyl-1-phenylethyl)(phenyl)phosphinic acid

(1-methyl-1-phenylethyl)(phenyl)phosphinic acid ethyl ester

Downstream raw materials:

N-hydroxylamine