C₂₉H₃₆N₂O₃S(C₂H₂O)

Base Information

• Chemical Name: C₂₉H₃₆N₂O₃S(C₂H₂O)
• CAS No.: 793724-08-0
• Molecular Formula: C₃₁H₃₈N₂O₄S
• Molecular Weight: 534.72
• Mol file: 793724-08-0.mol

Synonyms:

Chemical Property of C₂₉H₃₆N₂O₃S(C₂H₂O)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₆N₂O₃S(C₂H₂O)

There total 12 articles about C₂₉H₃₆N₂O₃S(C₂H₂O) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H36N2O3S(C2H2O)2 → C29H36N2O3S(C2H2O) (793724-08-0)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1016/j.tet.2004.06.141

Reference yield:

trimethyl-(2-nitro-phenyl)-stannane (76074-18-5) → C29H36N2O3S(C2H2O) (793724-08-0)

Guidance literature:

Multi-step reaction with 11 steps

1: 100 percent / Pd₂(dba)3*CHCl₃; Ph₃As; CuI / dimethylformamide / 48 h / 20 °C

2: 100 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / 20 °C

3: 100 percent / 3HF*Et₃N / tetrahydrofuran / 50 h / 20 °C

4: N,N-diisoropylethylamine / CH₂Cl₂ / 0.5 h / -78 °C

5: N,N-diisoropylethylamine / CH₂Cl₂ / 1 h / -78 °C

6: 10.0 mg / Zn; aq. NH₄Cl / methanol / 2 h / 20 °C

7: 86 percent / 4 Angstroem molecular sieves; DMTSF / CH₂Cl₂ / 2 h / 20 °C

8: 68 percent / NaBH₃CN; TiCl₄ / CH₂Cl₂; tetrahydrofuran / 1 h / -78 °C

9: TBAF / tetrahydrofuran / 45 °C

10: pyridine

11: NaOMe / methanol

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; triphenyl-arsane; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium methylate; titanium tetrachloride; sodium cyanoborohydride; ammonium chloride; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Stille coupling;

DOI:10.1016/j.tet.2004.06.141

Reference yield:

(5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one (482351-07-5) → C29H36N2O3S(C2H2O) (793724-08-0)

Guidance literature:

Multi-step reaction with 8 steps

1: N,N-diisoropylethylamine / CH₂Cl₂ / 0.5 h / -78 °C

2: N,N-diisoropylethylamine / CH₂Cl₂ / 1 h / -78 °C

3: 10.0 mg / Zn; aq. NH₄Cl / methanol / 2 h / 20 °C

4: 86 percent / 4 Angstroem molecular sieves; DMTSF / CH₂Cl₂ / 2 h / 20 °C

5: 68 percent / NaBH₃CN; TiCl₄ / CH₂Cl₂; tetrahydrofuran / 1 h / -78 °C

6: TBAF / tetrahydrofuran / 45 °C

7: pyridine

8: NaOMe / methanol

With pyridine; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium methylate; titanium tetrachloride; sodium cyanoborohydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tet.2004.06.141

upstream raw materials:

trimethyl-(2-nitro-phenyl)-stannane

(3R)-3-[(1E)-3-[(4-methoxyphenyl)methoxy]-1-[[[tris-(1-methylethyl)silyl]oxy]methyl]-1-propenyl]cyclohexanone

(5R,6R)-5-[(1E)-1-(hydroxymethyl)-3-[(4-methoxyphenyl)methoxy]-1-propenyl]-2-(2-nitrophenyl)-6-[[[2-(trimethylsilyl)ethoxy]methoxy]methyl]-2-cyclohexen-1-one

(5R,6R)-6-hydroxymethyl-5-[(1E)-3-[(4-methoxyphenyl)methoxy]-1-[[[tris-(1-methylethyl)silyl]oxy]methyl]-1-propenyl]-2-(2-nitrophenyl)-2-cyclohexen-1-one

Refernces