4-Methyl-alpha-oxo-2-phenyl-5-thiazoleacetic acid

Base Information

• Chemical Name: 4-Methyl-alpha-oxo-2-phenyl-5-thiazoleacetic acid
• CAS No.: 57561-00-9
• Molecular Formula: C₁₂H₉NO₃S
• Molecular Weight: 247.274
• DSSTox Substance ID: DTXSID901252358

Synonyms:4-Methyl-alpha-oxo-2-phenyl-5-thiazoleacetic acid;DTXSID901252358;57561-00-9

Chemical Property of 4-Methyl-alpha-oxo-2-phenyl-5-thiazoleacetic acid

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 247.03031432
• Heavy Atom Count: 17
• Complexity: 315

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(SC(=N1)C2=CC=CC=C2)C(=O)C(=O)O

Technology Process of 4-Methyl-alpha-oxo-2-phenyl-5-thiazoleacetic acid

There total 3 articles about 4-Methyl-alpha-oxo-2-phenyl-5-thiazoleacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-acetyl-4-methyl-2-phenylthiazole (7520-94-7) → 2-Phenyl-4-methyl-thiazol-5-yl-glyoxylsaeure (57561-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SeO₂ / aq. acetic acid / 2 h / Heating

2: 10percent aq. NaOH, 2.5percent aq. KMnO₄ / 0.5 h / Ambient temperature

With sodium hydroxide; potassium permanganate; selenium(IV) oxide; In acetic acid;

DOI:10.1002/ardp.19813140904

Reference yield:

2-Phenyl-4-methyl-5-glyoxyloyl-thiazol (80269-16-5) → 2-Phenyl-4-methyl-thiazol-5-yl-glyoxylsaeure (57561-00-9)

Guidance literature:

With sodium hydroxide; potassium permanganate; for 0.5h; Ambient temperature;

DOI:10.1002/ardp.19813140904

Reference yield:

→ 2-Phenyl-4-methyl-thiazol-5-yl-glyoxylsaeure (57561-00-9)

Guidance literature:

Va,KOH (Hydrolyse);

upstream raw materials:

2-Phenyl-4-methyl-5-glyoxyloyl-thiazol

5-acetyl-4-methyl-2-phenylthiazole

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