5-benzylidene-3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one

Base Information

• Chemical Name: 5-benzylidene-3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one
• CAS No.: 979-56-6
• Molecular Formula: C₂₁H₁₅N₃OS
• Molecular Weight: 357.436

Synonyms:

Chemical Property of 5-benzylidene-3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one

Chemical Property:

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Technology Process of 5-benzylidene-3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one

There total 2 articles about 5-benzylidene-3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2'-pyridyl)-3-phenylthiourea (886-60-2) → 5-benzylidene-3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one (979-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOAc / acetic acid / Heating

2: NaOAc / acetic acid / Heating

With sodium acetate; In acetic acid;

Reference yield:

benzaldehyde (100-52-7) + 3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one (961-53-5) → 5-benzylidene-3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one (979-56-6)

Guidance literature:

With sodium acetate; In acetic acid; Heating;

Reference yield:

5-benzylidene-3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one (979-56-6) → 5-bromo-5-(bromo-phenyl-methyl)-3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one

Guidance literature:

With bromine; In chloroform;

upstream raw materials:

benzaldehyde

3-phenyl-2-pyridin-2-ylimino-thiazolidin-4-one

1-(2'-pyridyl)-3-phenylthiourea

Refernces

Reductive amination with 5-ethyl-2-methylpyridine borane

10.1016/j.tetlet.2008.06.095

The research focuses on the development and application of a new amine borane complex, 5-ethyl-2-methylpyridine borane (PEMB), for reductive amination reactions of ketones and aldehydes. The study compares PEMB to other reagents like pyridine borane (PYB) and 2-picoline borane (PICB) in terms of efficiency, cost-effectiveness, and reaction conditions. The experiments involved using PEMB in various reductive amination reactions with different aldehyde or ketone/amine pairs, employing a 2:2:1 ratio for the carbonyl, amine, and PEMB, and in some cases, without solvent to increase volume productivity and reduce waste. The reactions were typically carried out at ambient temperature, with some requiring heating to increase the rate. The study analyzed the yields and reaction times of these processes, finding that PEMB was highly effective, selective, and faster than PICB in solvent-less conditions. The analyses used included gas chromatography (GC) to determine yields and nuclear magnetic resonance (NMR) to characterize the products.

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