N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Base Information

Chemical Name:N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide
CAS No.:184166-81-2
Molecular Formula:C₄₈H₄₉N₅O₆Si
Molecular Weight:820.032
Hs Code.:

N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

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Suppliers and Price of N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

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Chemical Property of N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

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Technology Process of N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

There total 1 articles about N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 98-88-4
benzoyl chloride

: 9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylamine

: 184166-81-2
N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: With pyridine; for 7h; Ambient temperature;
DOI:10.1016/0968-0896(96)00139-3

Reference yield:

: 184166-81-2
N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

: 184167-11-1
5-[(3aR,4R,6R,6aR)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-7-(tert-butyl-diphenyl-silanyloxy)-1-phenyl-1-trimethylsilanyl-hept-3-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) M LDA, 2.) CuCN, LiCl, 3.) ZnI₂, Simmons-Smith reagent

2: 81 percent / conc. aq. NH₃ / methanol / 18 h

With ammonium hydroxide; (iodomethyl)zinc iodide; lithium chloride; zinc(II) iodide; lithium diisopropyl amide; In methanol;
DOI:10.1016/0968-0896(96)00139-3

Reference yield:

: 184166-81-2
N-Benzoyl-N-[9-((3aR,4R,6R,6aR)-6-{2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-but-3-ynyl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-benzamide

: 184167-15-5
9-{(3aR,4R,6R,6aR)-6-[2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-6-phenyl-6-(tetrahydro-pyran-4-yloxy)-hex-3-ynyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) M LDA, 2.) CuCN, LiCl, 3.) ZnI₂, Simmons-Smith reagent

2: 81 percent / conc. aq. NH₃ / methanol / 18 h

3: 82 percent / KOBut / tetrahydrofuran / 1.75 h / 0 °C

4: 45 percent / PPTS / CH₂Cl₂

With ammonium hydroxide; potassium tert-butylate; pyridinium p-toluenesulfonate; (iodomethyl)zinc iodide; lithium chloride; zinc(II) iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0968-0896(96)00139-3