methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Base Information

Chemical Name:methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate
CAS No.:1609201-33-3
Molecular Formula:C₃₁H₄₃FN₂O₆SSi
Molecular Weight:618.842
Hs Code.:

methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Chemical Property of methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Technology Process of methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

There total 15 articles about methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609122-85-1
4-fluoro-2-[(R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-3-ylmethyl]benzenesulfonyl chloride

: 1609201-33-3
methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 4 h / 20 °C

2: potassium carbonate / methanol / 2.5 h / 20 - 55 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 22 h / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; potassium carbonate; In methanol; dichloromethane;

Reference yield:

: 1412977-28-6
tert butyl (R)-3-(3-fluorobenzyl)-pyrrolidine-1-carboxylate

: 1609201-33-3
methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

1.2: 0.5 h / Cooling with ice

2.1: chlorosulfonic acid / chloroform / 0.75 h / 20 °C / Cooling with ice

3.1: pyridine / dichloromethane / 4 h / 20 °C

4.1: potassium carbonate / methanol / 2.5 h / 20 - 55 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 22 h / 20 °C

With pyridine; chlorosulfonic acid; sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; chloroform;

Reference yield:

: 1609122-86-2
2,2,2-trifluoro-1-[(R)-3-(3-fluorobenzyl)pyrrolidin-1-yl]ethanone

: 1609201-33-3
methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: chlorosulfonic acid / chloroform / 0.75 h / 20 °C / Cooling with ice

2: pyridine / dichloromethane / 4 h / 20 °C

3: potassium carbonate / methanol / 2.5 h / 20 - 55 °C

4: sodium tris(acetoxy)borohydride / dichloromethane / 22 h / 20 °C

With pyridine; chlorosulfonic acid; sodium tris(acetoxy)borohydride; potassium carbonate; In methanol; dichloromethane; chloroform;