1609122-86-2

Upstream product

• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 
• 768-35-4 3-fluorophenylboronic acid 
• 1187932-69-9 (R)-tert-butyl 3-(iodomethyl)pyrrolidine-1-carboxylate 
• 1412977-28-6 tert butyl (R)-3-(3-fluorobenzyl)-pyrrolidine-1-carboxylate 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1609122-58-8 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid 
• 1609122-82-8 methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate 
• 1609122-83-9 methyl 7-fluoro-5-[4-fluoro-2-((R)-1-pyrrolidin-3-ylmethyl)benzene-sulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate 
• 1609122-84-0 methyl 7-fluoro-5-{4-fluoro-2-[(R)-1-(2,2,2-trifluoro-acetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate 
• 1609122-85-1 4-fluoro-2-[(R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-3-ylmethyl]benzenesulfonyl chloride 
• 1609201-09-3 methyl (1aR,7bS)-5-{4-fluoro-2-[(R)-1-(trifluoroacetyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate 
• 1609201-08-2 methyl (1aR,7bS)-5-[4-fluoro-2-((R)-pyrrolidin-3-ylmethyl)benzenesulfonylamino]-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate 
• 1609201-14-0 methyl (1aR,7bS)-5-{4-fluoro-2-[(R)-1-(2-hydroxy-2-methylpropyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate 
• 1609201-33-3 methyl (1aR,7bS)-5-{(2-[(R)-1-(2-tert-butyldimethylsilyloxyethyl)pyrrolidin-3-ylmethyl]-4-fluorobenzenesulfonylamino)}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate 
• 1609201-32-2 methyl (1aR,7bS)-5-{4-fluoro-2-[(R)-1-(2-hydroxyethyl)pyrrolidin-3-ylmethyl]benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate 

Relevant academic research and scientific papers

TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME

The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

TRICYCLIC COMPOUNDS FOR USE IN THE TREATMENT AND/OR CONTROL OF OBESITY

The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against me