ethyl 4-Bromo-1-naphthoate

Base Information

• Chemical Name: ethyl 4-Bromo-1-naphthoate
• CAS No.: 51934-43-1
• Molecular Formula: C₁₃H₁₁BrO₂
• Molecular Weight: 279.133
• Hs Code.: 2916399090
• Mol file: 51934-43-1.mol

Synonyms:

Chemical Property of ethyl 4-Bromo-1-naphthoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-Bromo-1-naphthoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-Bromo-1-naphthoate

There total 6 articles about ethyl 4-Bromo-1-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethanol (64-17-5) + 4-bromonaphthalene-1-carboxylic acid (16650-55-8) → ethyl 4-Bromo-1-naphthoate (51934-43-1)

Guidance literature:

With sulfuric acid; for 20h; Reflux;

DOI:10.1002/ejoc.201201752

Reference yield:

4-Bromo-1-naphthylamine (2298-07-9) → ethyl 4-Bromo-1-naphthoate (51934-43-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate; tert.-butylnitrite / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / -15 °C

1.2: 2 h / Reflux

2.1: sulfuric acid / water; acetic acid / 20 h / Reflux

3.1: sulfuric acid / 20 h / Reflux

With tert.-butylnitrite; sulfuric acid; boron trifluoride diethyl etherate; In tetrahydrofuran; 1,2-dimethoxyethane; water; acetic acid; 1.1: |Sonogashira Cross-Coupling / 1.2: |Sonogashira Cross-Coupling;

DOI:10.1002/ejoc.201201752

Reference yield:

4-bromonaphthalene-1-carbonitrile (92616-49-4) → ethyl 4-Bromo-1-naphthoate (51934-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / water; acetic acid / 20 h / Reflux

2: sulfuric acid / 20 h / Reflux

With sulfuric acid; In water; acetic acid;

DOI:10.1002/ejoc.201201752

upstream raw materials:

4-Bromo-1-naphthylamine

ethanol

4-bromonaphthalene-1-carboxylic acid

4-bromonaphthalene-1-carbonitrile

Downstream raw materials:

4-Ethoxycarbonyl-1-naphthylamine