thymidine 5'-phosphate

Base Information

• Chemical Name: thymidine 5'-phosphate
• CAS No.: 15108-71-1
• Molecular Formula: C₁₀H₁₅N₂O₈P
• Molecular Weight: 322.211
• Mol file: 15108-71-1.mol

Synonyms:

Chemical Property of thymidine 5'-phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of thymidine 5'-phosphate

There total 95 articles about thymidine 5'-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1)

Guidance literature:

With tris(p-nitrophenyl)phosphate; at 50 ℃; Erwina herbicola 47/3 cells;

DOI:10.1007/BF00598099

Reference yield:

C10H13N2O5Pol → thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1)

Guidance literature:

C₁₀H₁₃N₂O₅Pol; With 1H-tetrazole; C₆₀H₆₀NO₆P; In acetonitrile; for 0.1h; Succinyl Long Chain Alkylamine Controlled-Pore Glass

With pyridine; water; iodine; In tetrahydrofuran; for 0.5h; Succinyl Long Chain Alkylamine Controlled-Pore Glass

With ammonium hydroxide; In water; at 50 ℃; for 5h; Succinyl Long Chain Alkylamine Controlled-Pore Glass Reagent/catalyst;

DOI:10.1016/j.tetlet.2017.02.034

Reference yield:

NovaSynTM Tentagel resin-S-bound [2-(5-O-thymidine)-1,3,2-oxathiaphospholan-4-yl]methanethiol → thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1)

Guidance literature:

NovaSyn^TM Tentagel resin-S-bound [2-(5-O-thymidine)-1,3,2-oxathiaphospholan-4-yl]methanethiol; With tert.-butylhydroperoxide; In tetrahydrofuran; decane; at 20 ℃; for 1h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-Hydroxypropionitrile; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/ol050385w

upstream raw materials:

3'-O-acetylthymidine

[5']thymidylic acid monobenzyl ester

dibenzyl phosphochloridate

thymidine

Downstream raw materials:

thymin

thymidine

methanol

thymidine 5'-phosphate sodium salt