Cyclic 3',5'-thymidine monophosphate

Base Information

• Chemical Name: Cyclic 3',5'-thymidine monophosphate
• CAS No.: 6453-60-7
• Deprecated CAS: 6618-82-2
• Molecular Formula: C10H13 N2 O7 P
• Molecular Weight: 304.196
• UNII: I4N756M3GW
• DSSTox Substance ID: DTXSID80214800
• Metabolomics Workbench ID: 37875,149106
• Nikkaji Number: J635.444K
• Wikidata: Q27145158
• Mol file: 6453-60-7.mol

Synonyms:3',5'-cyclic dTMP;cTMP;cyclic 3',5'-thymidine monophosphate;cyclic TMP

Chemical Property of Cyclic 3',5'-thymidine monophosphate

Chemical Property:

• PSA: 129.66000
• Density: 1.66g/cm³
• LogP: -0.35170
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 1
• Exact Mass: 304.04603776
• Heavy Atom Count: 20
• Complexity: 548

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN(C(=O)NC1=O)C2CC3C(O2)COP(=O)(O3)O
• Isomeric SMILES: CC1=CN(C(=O)NC1=O)[C@H]2C[C@H]3[C@H](O2)COP(=O)(O3)O

Technology Process of Cyclic 3',5'-thymidine monophosphate

There total 6 articles about Cyclic 3',5'-thymidine monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1) + dicyclohexyl-carbodiimide (538-75-0) → 2'-deoxythymidine 3',5'-cyclic monophosphate (6453-60-7,6618-82-2)

Guidance literature:

With pyridine;

DOI:10.1021/ja01556a017

Reference yield:

2'-Deoxythymidin-3'-monophosphat → 2'-deoxythymidine 3',5'-cyclic monophosphate (6453-60-7,6618-82-2)

Guidance literature:

With potassium tert-butylate; chlorophosphoric acid diphenyl ester;

DOI:10.1039/c39870000594

Reference yield:

→ 2'-deoxythymidine 3',5'-cyclic monophosphate (6453-60-7,6618-82-2)

Guidance literature:

Thymidin-5'-phosphat <4-Morpholino-N,N'-dicyclohexylcarboxamidinium-Salz>, DCC;

DOI:10.1021/ja01062a036

upstream raw materials:

thymidine 5'-phosphate

dicyclohexyl-carbodiimide

Downstream raw materials:

thymin

Refernces

• 1、 Okruszek, Andrzej,Guga, Piotr,Stec, Wojciech J.. "Novel Approach to the Synthesis of Isotopomeric MonoalkylPhosphates. The Stereospecific One-pot Conversion of (Rp)-Thymidine 3'-(Nitrophenyl)-phosphorothioate into (Rp)-3'-ThymidinePhosphate". . p. 594 - 595. Retrieved 1987.
• 2、 Eckstein,Rizk. "Synthesis of oligodesoxynucleotides with phosphoric acid triester". . p. 2362 - 2377. Retrieved 2007/10/04.