Technology Process of 2-{4-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-hydroxy-ethoxy)-propyl]-phenyl}-isoindole-1,3-dione
There total 10 articles about 2-{4-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(2-hydroxy-ethoxy)-propyl]-phenyl}-isoindole-1,3-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
at 110 - 120 ℃;
for 0.133333h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: Et3N / CH2Cl2 / 0.25 h
2: 50 percent / HNO3 / 5 h / Ambient temperature
3: 99 percent / NaOMe / methanol
4: 93 percent / Fe, AcOH / acetone; H2O / 1.5 h / Heating
5: 76 percent / acetic acid / 1 h / Heating
6: 98 percent / 30percent H2O2 / acetic acid / 0.25 h / 80 - 85 °C
7: 90 percent / NaOAc / 3 h / Heating
8: 2.) SnCl4 / 2.) CH2Cl2
9: 84 percent / SO2Cl2 / CH2Cl2 / 2 h
10: 67 percent / 0.13 h / 110 - 120 °C
With
sulfuryl dichloride; dihydrogen peroxide; nitric acid; sodium methylate; sodium acetate; tin(IV) chloride; iron; acetic acid; triethylamine;
In
methanol; dichloromethane; water; acetic acid; acetone;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 50 percent / HNO3 / 5 h / Ambient temperature
2: 99 percent / NaOMe / methanol
3: 93 percent / Fe, AcOH / acetone; H2O / 1.5 h / Heating
4: 76 percent / acetic acid / 1 h / Heating
5: 98 percent / 30percent H2O2 / acetic acid / 0.25 h / 80 - 85 °C
6: 90 percent / NaOAc / 3 h / Heating
7: 2.) SnCl4 / 2.) CH2Cl2
8: 84 percent / SO2Cl2 / CH2Cl2 / 2 h
9: 67 percent / 0.13 h / 110 - 120 °C
With
sulfuryl dichloride; dihydrogen peroxide; nitric acid; sodium methylate; sodium acetate; tin(IV) chloride; iron; acetic acid;
In
methanol; dichloromethane; water; acetic acid; acetone;
