2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Base Information

Chemical Name:2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester
CAS No.:192774-11-1
Molecular Formula:C₄₃H₅₁N₃O₆S
Molecular Weight:737.96
Hs Code.:

2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

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Chemical Property of 2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Chemical Property:

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Technology Process of 2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

There total 10 articles about 2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

: 192774-11-1
2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: BOP; Et₃N / CH₂Cl₂

2: H₂ / Pd(OH)2/C / ethanol

3: pyridine

4: LiAlH₄ / tetrahydrofuran / 0 °C

5: Me₂SO₄ / CDCl₃ / -10 - -5 °C

6: NaBH₄ / methanol / -5 °C

7: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dimethyl sulfate; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform-d1; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8

Reference yield:

: 192774-14-4
4-(4-nitrophenyl)butyric acid, N-methoxy-N-methylamide

: 192774-11-1
2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd(OH)2/C / ethanol

2: pyridine

3: LiAlH₄ / tetrahydrofuran / 0 °C

4: Me₂SO₄ / CDCl₃ / -10 - -5 °C

5: NaBH₄ / methanol / -5 °C

6: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; N-ethyl-N,N-diisopropylamine; dimethyl sulfate; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform-d1; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8

Reference yield:

: 36924-81-9
ethyl 2-(4-aminophenyl)-2-methylpropanoate

: 192774-11-1
2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. NaNO₂; HCl

1.2: SnCl₂; concd HCl

2.1: H₂SO₄ / Heating

3.1: Me₂SO₄ / CDCl₃ / -10 - -5 °C

4.1: NaBH₄ / methanol / -5 °C

5.1: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; N-ethyl-N,N-diisopropylamine; dimethyl sulfate; sodium nitrite; In tetrahydrofuran; methanol; chloroform-d1; dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8