Benzoic acid, 3,5-diamino-, [1,1'-biphenyl]-4-yl ester

Base Information

• Chemical Name: Benzoic acid, 3,5-diamino-, [1,1'-biphenyl]-4-yl ester
• CAS No.: 136951-59-2
• Molecular Formula: C19H16N2O2
• Molecular Weight: 304.348
• Mol file: 136951-59-2.mol

Synonyms:

Chemical Property of Benzoic acid, 3,5-diamino-, [1,1'-biphenyl]-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 3,5-diamino-, [1,1'-biphenyl]-4-yl ester

There total 3 articles about Benzoic acid, 3,5-diamino-, [1,1'-biphenyl]-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-biphenyl 3,5-di-tert-butoxycarbonylaminobenzoate → 4-biphenyl 3,5-diaminobenzoate (136951-59-2)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; for 24h;

DOI:10.1080/15421406.2012.687889

Reference yield:

3.5-diaminobenzoic acid (535-87-5) → 4-biphenyl 3,5-diaminobenzoate (136951-59-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 0 - 20 °C / Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

3: toluene-4-sulfonic acid / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 24 h / 20 °C

With dmap; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;

DOI:10.1080/15421406.2012.687889

Reference yield:

3,5-di-(tert-butyloxycarbonylamino)benzoic acid (133887-83-9) → 4-biphenyl 3,5-diaminobenzoate (136951-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C

2: toluene-4-sulfonic acid / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 24 h / 20 °C

With dmap; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;

DOI:10.1080/15421406.2012.687889

upstream raw materials:

3.5-diaminobenzoic acid

3,5-di-(tert-butyloxycarbonylamino)benzoic acid

Refernces