7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene

Base Information

• Chemical Name: 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene
• CAS No.: 280143-73-9
• Molecular Formula: C₂₆H₁₇Cl₃N₆
• Molecular Weight: 519.82
• Mol file: 280143-73-9.mol

Synonyms:

Chemical Property of 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene

There total 4 articles about 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-chloro-phenyl)-[5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalen-7-yl]-(3-methyl-3H-imidazol-4-yl)-methanol (280143-53-5) → 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene (280143-73-9)

Guidance literature:

With thionyl chloride; at 40 ℃;

DOI:10.1016/j.bmcl.2003.08.080

Reference yield:

[2-amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)-methanone (190898-78-3) → 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene (280143-73-9)

Guidance literature:

Multi-step reaction with 6 steps

1: toluene / 110 °C

2: t-BuOK / 1,2-dimethoxy-ethane / 20 °C

3: POCl₃ / 80 °C

4: n-BuLi / tetrahydrofuran / -70 °C

5: 41 percent / NaN₃ / dimethylformamide / 90 °C

6: SOCl₂ / 40 °C

With n-butyllithium; thionyl chloride; sodium azide; potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2003.08.080

Reference yield:

N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide (405548-67-6) → 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene (280143-73-9)

Guidance literature:

Multi-step reaction with 5 steps

1: t-BuOK / 1,2-dimethoxy-ethane / 20 °C

2: POCl₃ / 80 °C

3: n-BuLi / tetrahydrofuran / -70 °C

4: 41 percent / NaN₃ / dimethylformamide / 90 °C

5: SOCl₂ / 40 °C

With n-butyllithium; thionyl chloride; sodium azide; potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.08.080

upstream raw materials:

(4-chloro-phenyl)-[5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalen-7-yl]-(3-methyl-3H-imidazol-4-yl)-methanol

[2-amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)-methanone

N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide

(+/-)-2-chloro-4-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinolinemethanol