405548-67-6

Basic information

• Product Name: N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide
• Synonyms: acetamide, N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]-; N-[2-(3-Chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide
• CAS NO: 405548-67-6
• Molecular Formula: C₂₂H₁₅Cl₂NO₃
• Molecular Weight: 412.2654
• Mol File: 405548-67-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 653.869°C at 760 mmHg
• Flash Point: 349.248°C
• Density: 1.362g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide(405548-67-6)
• EPA Substance Registry System: N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide(405548-67-6)

Safety Data

• Hazardous Substances Data: 405548-67-6(Hazardous Substances Data)

Upstream product

• 190898-77-2 3-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2,1-benzisoxazole 
• 190898-64-7 2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane 
• 7497-60-1 (4-Chlorophenyl)(4-nitrophenyl)methanone 
• 108-24-7 acetic anhydride 
• 190898-78-3 [2-amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)-methanone 

Downstream Products

• 405548-68-7 (4-chlorophenyl)[4-(3-chlorophenyl)-2-methyl-6-quinazolinyl]-methanone 
• 652131-06-1 (4-chloro-phenyl)-[5-(3-chloro-phenyl)-1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl]-(3-methyl-3H-imidazol-4-yl)-methanol 
• 280143-53-5 (4-chloro-phenyl)-[5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalen-7-yl]-(3-methyl-3H-imidazol-4-yl)-methanol 
• 280143-73-9 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-1,2,3,9b-tetraaza-cyclopenta[a]naphthalene 
• 280144-89-0 5-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-imidazol[1,2-a]quinoline-7-methanol 
• 652131-05-0 (4-chloro-phenyl)-[5-(3-chloro-phenyl)-[1,2,4]triazolo[4,3-a]quinolin-7-yl]-(3-methyl-3H-imidazol-4-yl)-methanol 
• 192185-72-1 tipifarnib 
• 192185-68-5 6-[amino(4-chlorophenyl)-1-methyl-1H-imidazol-5-ylmethyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone 
• 192185-51-6 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone 
• 192187-33-0 R₁₀₄₂₀₉ 
• 192187-32-9 R₁₀₁₇₆₃ 

Relevant articles and documents

Synthesis Routes Towards the Farnesyl Protein Transferase Inhibitor ZARNESTRA

The discovery that post-translational farnesylation of Ras oncoprotein was an essential step in exercising its biological effect led to the design of farnesyl protein transferase inhibitors (FTIs) in order to control growth of tumors bearing Ras mutations. Pre-clinical studies on murine models have confirmed their inhibitory effect on tumor growth and enabled clinical development. R115777 (ZARNESTRA) is currently undergoing clinical evaluation and recent studies have confirmed its antitumor potential and low toxicity. We wish to describe here the chemical synthesis routes that our group have developed to access ZARNESTRA. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Farnesyl transferase inhibiting 2-quinolone derivatives

The present invention is concerned with compounds of formula (I), STR1 the stereoisomeric forms thereof and the pharmaceutically acceptable acid or base addition salts thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; R