3-(1-hydroxy-1-cyclohexyl)-2-propynamide

Base Information

• Chemical Name: 3-(1-hydroxy-1-cyclohexyl)-2-propynamide
• CAS No.: 126491-76-7
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.208
• Mol file: 126491-76-7.mol

Synonyms:

Chemical Property of 3-(1-hydroxy-1-cyclohexyl)-2-propynamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-hydroxy-1-cyclohexyl)-2-propynamide

There total 5 articles about 3-(1-hydroxy-1-cyclohexyl)-2-propynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 3-(1-hydroxycyclohexyl)-2-propynoate (72036-33-0) → 3-(1-hydroxy-1-cyclohexyl)-2-propynamide (126491-76-7)

Guidance literature:

With ammonia; for 3h;

Reference yield:

1-<2-(carboethoxy)-ethynyl>cyclohexanol (76925-79-6) → 3-(1-hydroxy-1-cyclohexyl)-2-propynamide (126491-76-7)

Guidance literature:

With ammonium hydroxide;

DOI:10.1039/jr9460000503

Reference yield:

3-(1-hydroxycyclohexyl)propiolic acid (25294-58-0) → 3-(1-hydroxy-1-cyclohexyl)-2-propynamide (126491-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: aqueous ammonia

With ammonium hydroxide; sulfuric acid;

DOI:10.1039/jr9460000503

upstream raw materials:

1-<2-(carboethoxy)-ethynyl>cyclohexanol

methyl 3-(1-hydroxycyclohexyl)-2-propynoate

3-(1-hydroxycyclohexyl)propiolic acid

cyclohexanone