3-(1-HYDROXYCYCLOHEXYL)-2-PROPYNOIC ACID

Base Information

• Chemical Name: 3-(1-HYDROXYCYCLOHEXYL)-2-PROPYNOIC ACID
• CAS No.: 25294-58-0
• Molecular Formula: C₉H₁₂O₃
• Molecular Weight: 168.192
• Mol file: 25294-58-0.mol

Synonyms:3-(1-hydroxycyclohexyl)propiolic acid

Chemical Property of 3-(1-HYDROXYCYCLOHEXYL)-2-PROPYNOIC ACID

Chemical Property:

• Melting Point: 122-124.5 °C
• Boiling Point: 349.0±21.0 °C(Predicted)
• PKA: 2.45±0.10(Predicted)
• Density: 1.24±0.1 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

3-(1-Hydroxycyclohexyl)prop-2-ynoic acid ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of 3-(1-HYDROXYCYCLOHEXYL)-2-PROPYNOIC ACID

There total 6 articles about 3-(1-HYDROXYCYCLOHEXYL)-2-PROPYNOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-<2-(carboethoxy)-ethynyl>cyclohexanol (76925-79-6) → 3-(1-hydroxycyclohexyl)propiolic acid (25294-58-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.7b01351

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + propynoic acid methyl ester (922-67-8) → 3-(1-hydroxycyclohexyl)propiolic acid (25294-58-0)

Guidance literature:

With diethyl ether; sodium amide; anschliessend mit wss. H₂SO₄ behandeln;

DOI:10.1021/ja01162a054

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 3-(1-hydroxycyclohexyl)propiolic acid (25294-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: liquid NH₃

2: diethyl ether / anschliessend mit festem Kohlendioxid behandeln

With diethyl ether; ammonia;

DOI:10.1039/jr9460000503

upstream raw materials:

cyclohexanone

propynoic acid methyl ester

ethylmagnesium bromide

1-Ethynylcyclohexan-1-ol

Downstream raw materials:

1-<2-(carboethoxy)-ethynyl>cyclohexanol

methyl 3-(1-hydroxycyclohexyl)-2-propynoate

1-Ethynylcyclohexan-1-ol

3-(1-hydroxy-1-cyclohexyl)-2-propynamide