(S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester

Base Information

Chemical Name:(S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester
CAS No.:324530-48-5
Molecular Formula:C₆₇H₇₅N₃O₁₅
Molecular Weight:1162.34
Hs Code.:

(S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester

Synonyms:

Suppliers and Price of (S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester

There total 9 articles about (S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 324530-47-4
(S)-2-((S)-3-Carboxy-2-{(R)-3-(4-heptyloxy-phenoxy)-2-[((2R,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-carbonyl)-amino]-propionylamino}-propionylamino)-pentanedioic acid dibenzyl ester

: 324530-48-5
(S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester

Guidance literature:: With dmap; 4-(dimethylamino)pyridine hydrochloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; at 0 ℃;
DOI:10.1016/S0040-4039(00)01653-1

Reference yield:

: 97-30-3,617-04-9,709-50-2,1824-94-8,2152-78-5,3149-68-6,3396-99-4,6819-48-3,18469-06-2,20550-04-3,22277-65-2,29411-57-2,35437-40-2,35437-43-5,36191-11-4,36191-12-5,39598-79-3,39598-80-6,39598-89-5,51023-63-3,51223-62-2,51224-38-5,51224-39-6,51224-40-9,51224-41-0,51819-81-9,51819-82-0,51819-83-1,56688-81-4,62279-53-2,64281-79-4,64281-80-7,64912-19-2,66101-73-3,78184-90-4,84368-39-8,84368-40-1,84368-41-2,92142-37-5,93302-26-2,103421-28-9,115794-08-6
Methyl-D-galactopyranoside

: 324530-48-5
(S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: NaH; Bu₄NI / 4 h

2: 71 percent / TMSOTf / acetonitrile / 12 h

3: pyridine / 2 h

4: O₃; Me₂S / 8 h

5: CrO₃; aq. H₂SO₄ / acetone / 0.5 h

6: NaOMe / methanol / 1 h

7: EDC; HOBt; NMM / 2 h

8: Pd(PPh₃)4; morpholine / 1 h

9: 50 percent / EDC; DMAP; DMAP*HCl / 0 °C

With morpholine; 4-methyl-morpholine; pyridine; chromium(VI) oxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; sodium methylate; 4-(dimethylamino)pyridine hydrochloride; tetra-(n-butyl)ammonium iodide; sodium hydride; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; acetone; acetonitrile; 5: Jones oxidation;
DOI:10.1016/S0040-4039(00)01653-1

Reference yield:

: 324530-37-2
2,3,4,6-Tetra-O-benzyl-methyl-α/β-D-galactopyranoside

: 324530-48-5
(S)-2-{[(1R,4R,7S,12S,13R,14R,15S)-13,14,15-Tris-benzyloxy-4-(4-heptyloxy-phenoxymethyl)-2,5,9-trioxo-10,16-dioxa-3,6-diaza-bicyclo[10.3.1]hexadecane-7-carbonyl]-amino}-pentanedioic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 71 percent / TMSOTf / acetonitrile / 12 h

2: pyridine / 2 h

3: O₃; Me₂S / 8 h

4: CrO₃; aq. H₂SO₄ / acetone / 0.5 h

5: NaOMe / methanol / 1 h

6: EDC; HOBt; NMM / 2 h

7: Pd(PPh₃)4; morpholine / 1 h

8: 50 percent / EDC; DMAP; DMAP*HCl / 0 °C

With morpholine; 4-methyl-morpholine; pyridine; chromium(VI) oxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; sodium methylate; 4-(dimethylamino)pyridine hydrochloride; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; acetone; acetonitrile; 4: Jones oxidation;
DOI:10.1016/S0040-4039(00)01653-1