3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid bis-benzyloxy-phosphoryloxymethyl ester

Base Information

• Chemical Name: 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid bis-benzyloxy-phosphoryloxymethyl ester
• CAS No.: 247017-87-4
• Molecular Formula: C₄₆H₄₄N₃O₁₀P
• Molecular Weight: 829.843
• Mol file: 247017-87-4.mol

Synonyms:

Chemical Property of 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid bis-benzyloxy-phosphoryloxymethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid bis-benzyloxy-phosphoryloxymethyl ester

There total 3 articles about 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid bis-benzyloxy-phosphoryloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

silver dibenzylphosphate (50651-75-7) + 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid iodomethyl ester (247017-86-3) → 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid bis-benzyloxy-phosphoryloxymethyl ester (247017-87-4)

Guidance literature:

In toluene; Heating;

DOI:10.1016/S0960-894X(00)00183-9

Reference yield:

PD 154075 (158991-23-2) → 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid bis-benzyloxy-phosphoryloxymethyl ester (247017-87-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: KN(TMS)2 / tetrahydrofuran / -78 °C

1.2: 99 percent / tetrahydrofuran / -78 °C

2.1: 97 percent / NaI / acetone / Heating

3.1: 68 percent / toluene / Heating

With potassium hexamethylsilazane; sodium iodide; In tetrahydrofuran; acetone; toluene; 1.1: Metallation / 1.2: Acylation / 2.1: Iodination / 3.1: Substitution;

DOI:10.1016/S0960-894X(00)00183-9

Reference yield:

3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid chloromethyl ester (247017-85-2) → 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid bis-benzyloxy-phosphoryloxymethyl ester (247017-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / NaI / acetone / Heating

2: 68 percent / toluene / Heating

With sodium iodide; In acetone; toluene; 1: Iodination / 2: Substitution;

DOI:10.1016/S0960-894X(00)00183-9

upstream raw materials:

silver dibenzylphosphate

3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid iodomethyl ester

PD 154075

3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid chloromethyl ester