(2R,4aS,5aS,8R,9aR,9bR)-Perhydro-5-<(1R,4S)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>-2,8-diphenyl-2H,5H,8H-bis<1.3>dioxino<5,4-b:4',5'-d>pyrrole

Base Information

Chemical Name:(2R,4aS,5aS,8R,9aR,9bR)-Perhydro-5-<(1R,4S)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>-2,8-diphenyl-2H,5H,8H-bis<1.3>dioxino<5,4-b:4',5'-d>pyrrole
CAS No.:133378-87-7
Molecular Formula:C₂₇H₂₈N₂O₆
Molecular Weight:476.529
Hs Code.:

(2R,4aS,5aS,8R,9aR,9bR)-Perhydro-5-<(1R,4S)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>-2,8-diphenyl-2H,5H,8H-bis<1.3>dioxino<5,4-b:4',5'-d>pyrrole

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Suppliers and Price of (2R,4aS,5aS,8R,9aR,9bR)-Perhydro-5-<(1R,4S)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>-2,8-diphenyl-2H,5H,8H-bis<1.3>dioxino<5,4-b:4',5'-d>pyrrole

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Chemical Property of (2R,4aS,5aS,8R,9aR,9bR)-Perhydro-5-<(1R,4S)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>-2,8-diphenyl-2H,5H,8H-bis<1.3>dioxino<5,4-b:4',5'-d>pyrrole

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Technology Process of (2R,4aS,5aS,8R,9aR,9bR)-Perhydro-5-<(1R,4S)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>-2,8-diphenyl-2H,5H,8H-bis<1.3>dioxino<5,4-b:4',5'-d>pyrrole

There total 6 articles about (2R,4aS,5aS,8R,9aR,9bR)-Perhydro-5-<(1R,4S)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>-2,8-diphenyl-2H,5H,8H-bis<1.3>dioxino<5,4-b:4',5'-d>pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 133378-83-3
(2R,4aS,5aS,8R,9aR,9bR)-Perhydro-2,8-diphenyl-2H,5H,8H-bis<1,3>dioxino<5,4-b:4',5'-d>pyrrole-5-carbohydroxamic acid

: 1165952-91-9
cyclohexa-1,3-diene

: 133378-87-7,133443-78-4
1,3:4,6-Di-O-benzylidene-2,5-dideoxy-2,5-<<(1S,4R)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>imino>-L-iditol

Guidance literature:: With tetrapropylammonium periodate; 4 A molecular sieve; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1002/hlca.19910740112

Reference yield: 71.0%

: 110590-25-5
(1R,4S)-2-Oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carbonyl chloride

: 133443-76-2,187343-15-3
(2R,4aS,5aS,8R,9aR,9bR)-Perhydro-2,8-diphenyl-2H,5H,8H-bis<1,3>dioxino<5,4-b:4',5'-d>pyrrole

: 133378-87-7,133443-78-4
(2R,4aS,5aS,8R,9aR,9bR)-Perhydro-5-<(1R,4S)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>-2,8-diphenyl-2H,5H,8H-bis<1.3>dioxino<5,4-b:4',5'-d>pyrrole

Guidance literature:: With water; potassium carbonate; In diethyl ether; Ambient temperature;
DOI:10.1002/hlca.19910740112

Reference yield:

: 111275-74-2
Trifluoro-methanesulfonic acid (2R,4S,5R,2'R,4'S,5'R)-2,2'-diphenyl-5'-trifluoromethanesulfonyloxy-[4,4']bi[[1,3]dioxanyl]-5-yl ester

: 133378-87-7,133443-78-4
1,3:4,6-Di-O-benzylidene-2,5-dideoxy-2,5-<<(1S,4R)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>imino>-L-iditol

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / aq. hydrazine / tetrahydrofuran

2: 91 percent / hydrogen / moist Raney Ni / ethanol / 4 h / Ambient temperature

3: 57 percent / pyridine / 168 h / 45 - 50 °C

4: 90 percent / (Pr₄N)IO₄, 4 Angstroem molecular sieves / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; tetrapropylammonium periodate; 4 A molecular sieve; hydrogen; hydrazine hydrate; nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/hlca.19910740112