111275-74-2

Upstream product

• 61490-28-6 1,3:4,6-di-O-benzylidene-D-mannitol 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 100-52-7 benzaldehyde 
• 69-65-8 mannitol 
• 28224-73-9 1,3:4,6-di-O-benzylidene-D-mannitol 

Downstream Products

• 111248-47-6 2,3:4,5-di-O-benzylidene-(3R,4R)-dihydroxy-(2S,5S)-bis(hydroxymethyl)pyrrolidine 
• 111248-46-5 N-amino-1,3:4,6-di-O-benzylidene-2,5-dideoxy-2,5-imino-L-iditol 
• 105015-44-9 (2S,3R,4R,5S)-3,4-dihydroxy-2,5-bis(hydroxymethyl)pyrrolidine 
• 133378-87-7 (2R,4aS,5aS,8R,9aR,9bR)-Perhydro-5-<(1R,4S)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>-2,8-diphenyl-2H,5H,8H-bis<1.3>dioxino<5,4-b:4',5'-d>pyrrole 
• 133378-87-7 1,3:4,6-Di-O-benzylidene-2,5-dideoxy-2,5-<<(1S,4R)-2-oxa-3-azabicyclo<2.2.2>oct-5-ene-3-carbonyl>imino>-L-iditol 
• 133378-83-3 (2R,4aS,5aS,8R,9aR,9bR)-Perhydro-2,8-diphenyl-2H,5H,8H-bis<1,3>dioxino<5,4-b:4',5'-d>pyrrole-5-carbohydroxamic acid 
• 133443-76-2 (2R,4aS,5aS,8R,9aR,9bR)-Perhydro-2,8-diphenyl-2H,5H,8H-bis<1,3>dioxino<5,4-b:4',5'-d>pyrrole 
• 111248-46-5 (2R,4aS,5aS,8R,9aR,9bR)-2,8-Diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-ylamine 

Relevant academic research and scientific papers

Synthesis of novel, azasugar-modified anthraquinone derivatives and their cytotoxicity

A series of novel, azasugar-modified 2-monosubstituted, 2,6- and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis(2-chloroacetamido)anthraquinones. Their cytotoxic activities against HeLa and MCF-7 cells were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug (Cisplatin).

D-Mannitol-derived novel chiral thioureas: Synthesis and application in asymmetric Henry reactions

Five novel thioureas have been obtained through multi-step reactions from D-Mannitol as starting material and applied as catalysts in the asymmetric Henry reaction. Using catalyst 7a, (1S,2R)-2-nitro-1-phenylpropan-1-ol containing two chiral centers was o

Studies on the formation of a tricyclic C2-symmetric sulfide

Attempts to synthesise chiral sulfide 1 from the dimesylate precursor 5, via a cyclisation reaction using sodium sulfide in dimethyl sulfoxide, led to the unexpected formation of an unsymmetrical furan derivative 8. Studies were made into the effect of changing the leaving group, and changing the solvent of reaction. The desired compound could be synthesized in good yields from the xanthate 9 using a radical-mediated procedure.

SYNTHESIS OF (2S,5S)-BISHYDROXYMETHYL-(3R,4R)-BISHYDROXYPYRROLIDINE FROM D-MANNITOL

A short, efficient, and practical synthesis of (2S,5S)-bishydroxymethyl-(3R,4R)-bishydroxypyrrolidine from D-mannitol involving five sequential reactions (benzylidenation, trifluoromethanesulphonation, hydrazinolysis, hydrogenolysis, and deacetalisation)

A Short and Practical Synthesis of (2S,5S)-Bishydroxymethyl-(3R,4R)-bishydroxypyrrolidine

D-Mannitol has been converted by five sequential reactions (benzylidenation, trifluoromethanesulphonation, hydrazinolysis, hydrogenolysis, and deacetalisation) into (2S,5S)-bishydroxymethyl-(3R,Ρ)-bishydroxypyrrolidine.