(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (9E,13E)-(1S,3S,4R,6S,15S)-4,9,13-trimethyl-18-methylene-17-oxo-5,16-dioxa-tricyclo[13.3.0.0^4,6]octadeca-9,13-dien-3-yl ester

Base Information

• Chemical Name: (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (9E,13E)-(1S,3S,4R,6S,15S)-4,9,13-trimethyl-18-methylene-17-oxo-5,16-dioxa-tricyclo[13.3.0.0^4,6]octadeca-9,13-dien-3-yl ester
• CAS No.: 122616-38-0
• Molecular Formula: C₃₀H₃₅F₃O₆
• Molecular Weight: 548.6

Synonyms:

Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (9E,13E)-(1S,3S,4R,6S,15S)-4,9,13-trimethyl-18-methylene-17-oxo-5,16-dioxa-tricyclo[13.3.0.0^4,6]octadeca-9,13-dien-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (9E,13E)-(1S,3S,4R,6S,15S)-4,9,13-trimethyl-18-methylene-17-oxo-5,16-dioxa-tricyclo[13.3.0.0^4,6]octadeca-9,13-dien-3-yl ester

There total 5 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (9E,13E)-(1S,3S,4R,6S,15S)-4,9,13-trimethyl-18-methylene-17-oxo-5,16-dioxa-tricyclo[13.3.0.0^4,6]octadeca-9,13-dien-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (9E,13E)-(1S,3S,4S,6S,15S)-3-Hydroxy-4,9,13-trimethyl-18-methylene-5,16-dioxa-tricyclo[13.3.0.04,6]octadeca-9,13-dien-17-one (122616-37-9) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (9E,13E)-(1S,3S,4R,6S,15S)-4,9,13-trimethyl-18-methylene-17-oxo-5,16-dioxa-tricyclo[13.3.0.04,6]octadeca-9,13-dien-3-yl ester (122616-38-0,122674-39-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)80593-6

Reference yield:

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + (9E,13E)-(1S,3S,4S,6S,15S)-3-Hydroxy-4,9,13-trimethyl-18-methylene-5,16-dioxa-tricyclo[13.3.0.04,6]octadeca-9,13-dien-17-one (122616-37-9) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (9E,13E)-(1S,3S,4R,6S,15S)-4,9,13-trimethyl-18-methylene-17-oxo-5,16-dioxa-tricyclo[13.3.0.04,6]octadeca-9,13-dien-3-yl ester (122616-38-0,122674-39-9)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 15h; Ambient temperature;

DOI:10.1021/ja00011a006

Reference yield:

Cembranolide A (75077-42-8) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (9E,13E)-(1S,3S,4R,6S,15S)-4,9,13-trimethyl-18-methylene-17-oxo-5,16-dioxa-tricyclo[13.3.0.04,6]octadeca-9,13-dien-3-yl ester (122616-38-0,122674-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LiOH / dioxane; H₂O

2: DMAP, Et₃N / CH₂Cl₂

With dmap; lithium hydroxide; triethylamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/S0040-4039(00)80593-6

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(9E,13E)-(1S,3S,4S,6S,15S)-3-Hydroxy-4,9,13-trimethyl-18-methylene-5,16-dioxa-tricyclo[13.3.0.0^4,6]octadeca-9,13-dien-17-one

Cembranolide A

Mosher's acid chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 122616-38-0 (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (9E,13E)-(1S,3S,4R,6S,15S)-4,9,13-trimethyl-18-methylene-17-oxo-5,16-dioxa-tricyclo[13.3.0.0^4,6]octadeca-9,13-dien-3-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send