2'-benzyl 2-methyl 4-(isobutylamino)carbonyl-4'-methylbiphenyl-2,2'-dicarboxylate

Base Information

Chemical Name:2'-benzyl 2-methyl 4-(isobutylamino)carbonyl-4'-methylbiphenyl-2,2'-dicarboxylate
CAS No.:790230-10-3
Molecular Formula:C₂₈H₂₉NO₅
Molecular Weight:459.542
Hs Code.:

Synonyms:

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Chemical Property of 2'-benzyl 2-methyl 4-(isobutylamino)carbonyl-4'-methylbiphenyl-2,2'-dicarboxylate

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Technology Process of 2'-benzyl 2-methyl 4-(isobutylamino)carbonyl-4'-methylbiphenyl-2,2'-dicarboxylate

There total 13 articles about 2'-benzyl 2-methyl 4-(isobutylamino)carbonyl-4'-methylbiphenyl-2,2'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 790230-04-5
4-bromo-3-(hydroxymethyl)benzoic acid

: 790230-10-3
2'-benzyl 2-methyl 4-(isobutylamino)carbonyl-4'-methylbiphenyl-2,2'-dicarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 4.27 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

2.1: MnO₂ / CHCl₃ / 1 h / 70 °C

3.1: 3.53 g / 4-methylbenzenesulfonic acid monohydrate / toluene / 12 h / Heating

4.1: n-butyl lithium / tetrahydrofuran; hexane / 2 h / -78 °C

4.2: triisopropyl borate / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

4.3: 280 mg / hydrochloric acid / tetrahydrofuran; hexane; H₂O / 3 h / 20 °C

5.1: K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 120 °C

6.1: NaH₂PO₄*2H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 12 h / 20 °C

7.1: 0.44 g / K₂CO₃ / dimethylformamide / 12 h / 20 °C

With manganese(IV) oxide; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; p-toluenesulfonic acid monohydrate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol; 5.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.010

Reference yield:

: 4-bromo-3-formyl-N-isobutyl-benzamide

: 790230-10-3
2'-benzyl 2-methyl 4-(isobutylamino)carbonyl-4'-methylbiphenyl-2,2'-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3.53 g / 4-methylbenzenesulfonic acid monohydrate / toluene / 12 h / Heating

2.1: n-butyl lithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: triisopropyl borate / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

2.3: 280 mg / hydrochloric acid / tetrahydrofuran; hexane; H₂O / 3 h / 20 °C

3.1: K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 120 °C

4.1: NaH₂PO₄*2H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 12 h / 20 °C

5.1: 0.44 g / K₂CO₃ / dimethylformamide / 12 h / 20 °C

With sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; p-toluenesulfonic acid monohydrate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol; 3.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.010

Reference yield:

: 254746-41-3
methyl 3-(acetyloxy)methyl-4-bromobenzoate

: 790230-10-3
2'-benzyl 2-methyl 4-(isobutylamino)carbonyl-4'-methylbiphenyl-2,2'-dicarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 8.29 g / NaOH / methanol; H₂O / 2 h / 20 °C

2.1: 4.27 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C

3.1: MnO₂ / CHCl₃ / 1 h / 70 °C

4.1: 3.53 g / 4-methylbenzenesulfonic acid monohydrate / toluene / 12 h / Heating

5.1: n-butyl lithium / tetrahydrofuran; hexane / 2 h / -78 °C

5.2: triisopropyl borate / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

5.3: 280 mg / hydrochloric acid / tetrahydrofuran; hexane; H₂O / 3 h / 20 °C

6.1: K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 120 °C

7.1: NaH₂PO₄*2H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 12 h / 20 °C

8.1: 0.44 g / K₂CO₃ / dimethylformamide / 12 h / 20 °C

With manganese(IV) oxide; sodium hydroxide; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; p-toluenesulfonic acid monohydrate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; hexane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol; 6.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.08.010