N'-{9-[(3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine

Base Information

Chemical Name:N'-{9-[(3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine
CAS No.:175876-75-2
Molecular Formula:C₄₁H₅₂N₆O₅Si
Molecular Weight:736.987
Hs Code.:

N'-{9-[(3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine

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Chemical Property of N'-{9-[(3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine

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Technology Process of N'-{9-[(3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine

There total 13 articles about N'-{9-[(3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130250-07-6
5-O-benzoyl-3-deoxy-3-<(benzyloxy)methyl>-1,2-O-isopropylidene-α-D-ribofuranose

: 175876-75-2
N'-{9-[(3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) TMSOTf, 2.) Et₃SiH / 1.) CH₂Cl₂, RT, 0.5 h, 2.) CH₂Cl₂, RT, 18 h

2: H₂ / 10percent Pd/C / methanol / 20 h / Ambient temperature

3: DMAP / pyridine / 23 h / Ambient temperature

4: 623 mg / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

5: 32 percent / K₂CO₃, 18-crown-6-ether / dimethylformamide / 20 h / 120 °C

6: methanolic ammonia / 48 h / Ambient temperature

7: methanol / 11 h / Ambient temperature

8: DMAP / pyridine / 2 h / Ambient temperature

With triethylsilane; dmap; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; ammonia; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00007-5

Reference yield:

: 69832-48-0,119100-05-9
3-C-deoxy-3-C-hydroxymethyl-1,2;5,6-di-O-isopropylidene-α-D-allo-furanose

: 175876-75-2
N'-{9-[(3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) NaH / 1.) DMF, RT, 40 min, 2.) DMF, RT, 13 h

2: 0.8 N H₂SO₄ / methanol / 48 h / Ambient temperature

3: NaIO₄ / methanol / 2.5 h / Ambient temperature

4: NaBH₄ / methanol / 2 h / Ambient temperature

5: pyridine / 2 h / Ambient temperature

6: 1.) TMSOTf, 2.) Et₃SiH / 1.) CH₂Cl₂, RT, 0.5 h, 2.) CH₂Cl₂, RT, 18 h

7: H₂ / 10percent Pd/C / methanol / 20 h / Ambient temperature

8: DMAP / pyridine / 23 h / Ambient temperature

9: 623 mg / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

10: 32 percent / K₂CO₃, 18-crown-6-ether / dimethylformamide / 20 h / 120 °C

11: methanolic ammonia / 48 h / Ambient temperature

12: methanol / 11 h / Ambient temperature

13: DMAP / pyridine / 2 h / Ambient temperature

With pyridine; triethylsilane; dmap; sodium tetrahydroborate; sodium periodate; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; ammonia; hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00007-5

Reference yield:

: 149207-10-3
(3aR,5S,6R,6aR)-6-Benzyloxymethyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole-5-carbaldehyde

: 175876-75-2
N'-{9-[(3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-9H-purin-6-yl}-N,N-dimethyl-formamidine

Guidance literature:: Multi-step reaction with 10 steps

1: NaBH₄ / methanol / 2 h / Ambient temperature

2: pyridine / 2 h / Ambient temperature

3: 1.) TMSOTf, 2.) Et₃SiH / 1.) CH₂Cl₂, RT, 0.5 h, 2.) CH₂Cl₂, RT, 18 h

4: H₂ / 10percent Pd/C / methanol / 20 h / Ambient temperature

5: DMAP / pyridine / 23 h / Ambient temperature

6: 623 mg / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

7: 32 percent / K₂CO₃, 18-crown-6-ether / dimethylformamide / 20 h / 120 °C

8: methanolic ammonia / 48 h / Ambient temperature

9: methanol / 11 h / Ambient temperature

10: DMAP / pyridine / 2 h / Ambient temperature

With pyridine; triethylsilane; dmap; sodium tetrahydroborate; 18-crown-6 ether; trimethylsilyl trifluoromethanesulfonate; ammonia; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00007-5