Mc-Val-Ala-PAB

Base Information

• Chemical Name: Mc-Val-Ala-PAB
• CAS No.: 1870916-87-2
• Molecular Formula: C₂₅H₃₄N₄O₆
• Molecular Weight: 486.568
• Mol file: 1870916-87-2.mol

Synonyms:

Chemical Property of Mc-Val-Ala-PAB

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

MC-Val-Ala-PAB ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Mc-Val-Ala-PAB

There total 10 articles about Mc-Val-Ala-PAB which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-aminobenzenemethanol (623-04-1) + (S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-hexanamido)-3-methylbutanamido)propanoic acid (1342211-31-7) → 6-(2,5-dioxo-2,5-dihydro-1H-pyrrole-1-yl)-N-[(S)-1-{[(S)-1-{[4-(hydroxymethyl)phenyl] amino}-1-oxopropan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]hexanamide (1870916-87-2)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In methanol; dichloromethane; at 20 ℃;

Reference yield: 87.0%

6-maleimidohexanoic acid N-hydroxylsuccinimide ester (55750-63-5) + (9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate (1343476-44-7) → 6-(2,5-dioxo-2,5-dihydro-1H-pyrrole-1-yl)-N-[(S)-1-{[(S)-1-{[4-(hydroxymethyl)phenyl] amino}-1-oxopropan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]hexanamide (1870916-87-2)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.3390/ijms18091860

Reference yield:

N-(9-fluorenylmethoxycarbonyl)-L-valyl-L-alanine (150114-97-9) → 6-(2,5-dioxo-2,5-dihydro-1H-pyrrole-1-yl)-N-[(S)-1-{[(S)-1-{[4-(hydroxymethyl)phenyl] amino}-1-oxopropan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]hexanamide (1870916-87-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran

2: N,N-dimethyl acetamide

3: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide

With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

upstream raw materials:

2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid

(9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

2,5-dioxopyrrolidin-1-yl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valinate

N-(9-fluorenylmethoxycarbonyl)-L-valyl-L-alanine

Downstream raw materials:

[4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate