ETHYL 4-CHLORO-2-FLUOROBENZOYLFORMATE

Base Information

• Chemical Name: ETHYL 4-CHLORO-2-FLUOROBENZOYLFORMATE
• CAS No.: 228998-72-9
• Molecular Formula: C₁₀H₈ClFO₃
• Molecular Weight: 230.623
• Mol file: 228998-72-9.mol

Synonyms:

Chemical Property of ETHYL 4-CHLORO-2-FLUOROBENZOYLFORMATE

Chemical Property:

• Vapor Pressure: 0.000618mmHg at 25°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-chloro-2-fluorobenzoylformate 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of ETHYL 4-CHLORO-2-FLUOROBENZOYLFORMATE

There total 1 articles about ETHYL 4-CHLORO-2-FLUOROBENZOYLFORMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1-bromo-4-chloro-2-fluorobenzene (1996-29-8) + oxalic acid diethyl ester (95-92-1) → ethyl 2-(4-chloro-2-fluorophenyl)-2-oxoacetate (228998-72-9)

Guidance literature:

1-bromo-4-chloro-2-fluorobenzene; With iodine; magnesium; In tetrahydrofuran; at 40 ℃; Inert atmosphere;

oxalic acid diethyl ester; In tetrahydrofuran; at -50 - 20 ℃; for 18h; Inert atmosphere;

Reference yield:

ethyl 2-(4-chloro-2-fluorophenyl)-2-oxoacetate (228998-72-9) → 5-chloro-4-[4-chloro-2-fluoro-5-(methylamino)phenyl]-1,2-tetramethylene-4-pyrazolin-3-one

Guidance literature:

Multi-step reaction with 7 steps

1: triphenylphosphine / dichloromethane / 22 h / 20 °C / Cooling with ice

2: triethylamine / 1,4-dioxane / 17 h / Reflux

3: sulfuric acid; nitric acid / Cooling with ice

4: hydrogenchloride; tin(II) chloride dihdyrate / water; ethanol / 42 h / Reflux

5: dmap / tetrahydrofuran / 1.5 h / 70 °C

6: sodium hydride / N,N-dimethyl-formamide / 24 h

7: hydrogenchloride / tetrahydrofuran; water / 6 h

With hydrogenchloride; dmap; tin(II) chloride dihdyrate; sulfuric acid; nitric acid; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

ethyl 2-(4-chloro-2-fluorophenyl)-2-oxoacetate (228998-72-9) → 5-chloro-4-[4-chloro-2-fluoro-5-(N-methyl-N-(propargyl) amino)phenyl]-1,2-tetramethylene-4-pyrazolin-3-one

Guidance literature:

Multi-step reaction with 8 steps

1: triphenylphosphine / dichloromethane / 22 h / 20 °C / Cooling with ice

2: triethylamine / 1,4-dioxane / 17 h / Reflux

3: sulfuric acid; nitric acid / Cooling with ice

4: hydrogenchloride; tin(II) chloride dihdyrate / water; ethanol / 42 h / Reflux

5: dmap / tetrahydrofuran / 1.5 h / 70 °C

6: sodium hydride / N,N-dimethyl-formamide / 24 h

7: hydrogenchloride / tetrahydrofuran; water / 6 h

8: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

With hydrogenchloride; dmap; tin(II) chloride dihdyrate; sulfuric acid; nitric acid; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

1-bromo-4-chloro-2-fluorobenzene

oxalic acid diethyl ester

Refernces

• 1、 -. "PYRAZOLINE-3-ON DERIVATIVE AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT". Paragraph 0157. . Retrieved 2016/10/08.